DETERMINATION OF FREE EMBRYONIC DNA IN THE PLASMA OF PREGNANT WOMEN FOR NONINVASIVE PRENATAL GENETIC DIAGNOSIS


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Abstract

The need for timely diagnosis with the minimum risk to mother and fetus determines whether it is urgent to make a noninvasive prenatal diagnosis. The detection of free (extracellular) embryonic DNA circulating in the maternal plasma has opened up fresh opportunities for the noninvasive genetic diagnosis of the fetus and the state of pregnancy. Embryonic DNA may be detected at 5—6 weeks’ gestation and promptly disappears after childbirth. Current molecular biological technologies to investigate this DNA make it possible to predict pregnancy complications, to define fetal sex and rhesus, and to diagnose gene and chromosomal mutations.

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About the authors

N. K TETRUASHVILI

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: tetrauly@mail.ru

N. I FEDOROVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: natasha_fedorova@mail.ru

L. Z FAIZULLIN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: lfaizullin@mail.ru

V. N KARNAUKHOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

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