IMMUNE FACTORS IN THE ETIOLOGY AND PATHOGENESIS OF PREGNANCY COMPLICATIONS


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Abstract

The paper gives current views of the role of immune mechanisms, particularly innate immunity factors that contribute to the formation and development of normal pregnancy and participate in the pathogenesis of pregnancy complications. Based on the data available in the literature and their own studies, the authors consider the immunological aspects of pregnancy complications, such as recurrent miscarriage and preeclampsia, and those associated with infectious and autoimmune processes. Whether immunological assays can be used to diagnose and predict impairments in normal pregnancy is analyzed.

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About the authors

G. T SUKHIKH

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

L. V VANKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of Russia

Email: LVanko@oparina4.ru

References

  1. Сидельникова В.М., Сухих Г.Т. Невынашивание беременности. - М.: МИА, 2010.
  2. Сухих Г.Т., Мурашко Л.Е. Преэклампсия: Руководство. -М., ГЭОТАР-Медиа, 2010.
  3. Goldman-Wohl D., Yagel S. Examination of distinct fetal and maternal molecular pathways suggests a mechanism for the development of preeclampsia // J.Reprod. Immunol. - 2007. - Vol. 76. - P. 54-60.
  4. Hill J.A., Choi B.C. Maternal immunological aspects of pregnancy success and failure // J. Reprod. Fertil. - 2000. -Vol. 55. - P. 91-97.
  5. Lunghi L., Ferretti M.E., Medici S. et al. Control of human trophoblast function // Reprod. Biol. Endocrinol. - 2007. -Vol. 5. - P. 6.
  6. Mor G., Romero R., Aldo P.B., Abrahams V.M. Is the trophoblast an immune regulator? The role of Toll-like receptors during pregnancy // Crit. Rev. Immunol. - 2005. - Vol. 25. -P. 375-388.
  7. Quenby S., Farquharson R. Uterine natural killer cells, implantation failure and recurrent miscarriage // Reprod. Biomed. Online. - 2006. - Vol. 13. - P. 24-28.
  8. Richani K., Soto E., Romero R. et al. Normal pregnancy is characterized by systemic activation of the complement system // J. Matern. Fetal Neonatal Med. - 2005. - Vol. 17. -P. 239-245.
  9. Robilland Р.-Y., Dekker G., Chaouat G., Hulsey T.C. Etiology of preeclampsia: maternal vascular predisposition and couple disease — mutual exclusion or complementarity? // J. Reprod. Immunol. - 2007. - Vol. 76. - P. 1-7.
  10. Saito S., Shima T., Nakashima A. et al. What is the role of regulatory T cells in the success of implantation and early pregnancy? // J. Assist. Reprod. Genet. - 2007. - Vol. 24, № 9. - P. 379-386.
  11. Sargent I.L., Borzychowski A.M., Redman C.W. NK cells and - 2006. - Vol. 27. - P. 399-404.
  12. Wang C.C., Yim K.W., Poon T.C. et al. Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia // Clin. Chem. - 2007. - Vol. 53. - P. 42-52.
  13. Wira C.R., Grant-Tschudy K.S., Crane-Godreau M.A. Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection // Am. J. Reprod. Immunol. - 2005. - Vol. 53. - P. 65-76.

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