CELL TECHNOLOGIES IN THE TREATMENT OF FEMALE STRESS URINARY INCONTINENCE


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Abstract

The problem of urinary incontinence (UI) in women has been recently more and more relevant, stress UI (SUI) being 51—77%. Conservative treatments for SUI and pharmacological agents are now ineffective while surgery may give rise serious complications. Due to the development of cell technologies and regenerative medicine, new approaches to treating SUI, which are based on the transplantation of stem/progenitor cells (SPCs) and tissue-engineering designs (TED), are being developed. Analysis of the scientific literature has demonstrated that many unsolved problems still remain in this f ield of regenerative medicine. In particular, there is no consensus of opinion on which type of cells should be chosen for transplantation, as before. The question of the mechanisms for therapeutic activity of cell transplantation in SUI remains debatable. However, this area shows just now a quite evident trend in the use of cells as carrier matrices, i.e. TEDs, rather than as suspension.

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About the authors

A. V MAKAROV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia; Research Institute of Human Morphology, Russian Academy of Medical Sciences

Email: anvitmak@yandex.ru

T. A TETERINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia

Email: palpebra@inbox.ru

A. S SAIDOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia

Email: Asekova14@yandex.ru

I. V ARUTYUNYAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia; Research Institute of Human Morphology, Russian Academy of Medical Sciences

Email: labrosta@yandex.ru

T. Kh FATKHUDINOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia; Research Institute of Human Morphology, Russian Academy of Medical Sciences

Email: tfat@yandex.ru

I. A APOLIKHINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia; I.M. Sechenov First Moscow State Medical University

Email: apolikhina@inbox.ru

G. T SUKHIKH

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health and Social Development of Russia; I.M. Sechenov First Moscow State Medical University

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