BLOCKING EFFECT OF AUTOLOGOUS SERUM IN WOMEN WITH RECURRENT MISCARRIAGE


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Abstract

Objective. To investigate the blocking effect (BE) of autologous sera on the activation of lymphocytes from women with a history of recurrent miscarriage (RM) in their preparation for pregnancy and during the latter. Subjects and methods. The BE of the sera was determined by flow cytometry in 31 women with RM and 11 fertile women Results. After pregestation preparation using immunocytotherapy (ICT), pregnancy ended in the birth of a live baby in 17 women with RM and a miscarriage occurred in 5. During the current pregnancy, BE was minimal at 8-9 weeks gestation and then increased by the end of the second trimester and in the third trimester. Conclusion. The assessment of the blocking activity of peripheral blood serum is seemingly promising for use as one of the laboratory criteria for the efficiency of pregestation preparation using ICT and as one of the indicators of threatened miscarriage in the women with RM at 8-9 weeks gestation.

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About the authors

L. V KRECHETOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: k_l_v_@mail.ru

M. A NIKOLAYEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nikolaeva_ma@mail.ru

L. V VANKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: LVanko@oparina4.ru

E. L GOLUBEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_golubeva@oparina4.ru

M. M ZIGANSHINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mmz@mail.ru

N. K TETRUASHVILI

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_tetruashvili@oparina4.ru

V. V VTORUSHINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: vtorushina@inbox.ru

G. T SUKHIKH

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_sukhikh@oparina4.ru

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