BIOCHEMICAL MARKERS OF THREATENED MISCARRIAGE
- Authors: KOVALENKO A.E1, KALININA N.N1, ALEKSEENKOVA M.V1, PANINA O.B1, SAVELYEVA G.M1
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Affiliations:
- M.V. Lomonosov Moscow University
- Issue: No 3 (2013)
- Pages: 43-47
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246905
- ID: 246905
Cite item
Open Access
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Abstract
Objective. To elaborate additional biochemical markers of threatened premature delivery. Subjects and method. The prospective investigation enrolled 52 patients with symptoms of threatened delivery. The diagnostic value of nonphosphorylated insulin-like growth factor-binding protein 1 (IGFBP-1) and interleukin-6 (IL-6) in the cervicovaginal secretion and that of progesterone and estradiol in the saliva was evaluated by enzyme immunoassay. Results. Significant differences were found in IL-6 levels in patients who had given birth prematurely or timely. ROC analysis indicated that the optimal sensitivity and specificity (100.0 and 42.1%, respectively) were observed at an IL-6 level of 66.79 pg/ml. The prognostic value of positive and negative results was 38.9 and 100%, respectively. Examination of IGFBP-1 in the cervical secretion and estradiol and progesterone in the saliva revealed no significant differences in the patients who had given birth prematurely and timely. Conclusion. The cervical secretion IL-6 concentration of less than 66.7 pg/ml allows patients at low risk for premature birth to be identified with a high degree of accuracy.
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About the authors
A. E KOVALENKO
M.V. Lomonosov Moscow University
Email: acromion19847@mail.ru
N. N KALININA
M.V. Lomonosov Moscow University
Email: n_i_kalinina@mail.ru
M. V ALEKSEENKOVA
M.V. Lomonosov Moscow University
O. B PANINA
M.V. Lomonosov Moscow University
Email: olgapanina@yandex.ru
G. M SAVELYEVA
M.V. Lomonosov Moscow University
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