ESTIMATION OF THE PLASMA CONCENTRATION OF ENDOTHELIN-1 AND SICAM-1 IN PREGNANT WOMEN WITH GESTATIONAL DIABETES MELLITUS


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Abstract

Objective. To estimate the plasma concentration of endothelin-1 and sICAM-1 in pregnant women with gestational diabetes mellitus (GDM). Subjects and methods. The study included 83 pregnant women who formed four comparison groups: 1) 25 patients with GDM on diet therapy (dGDM); 2) 25 with GDM on insulin therapy (iGDM); 3) 12 apparently healthy pregnant women without carbohydrate metabolic disturbance (a control group); 4) 21 with preeclampsia without carbohydrate metabolic disturbance (a comparison group). The diagnosis of GDM was established on the basis of a glucose tolerance test. The levels of endothelin-1 and sICAM-1 were determined using the standard test systems. Results. The highest values of endothelin-1 were found in the pregnant women with dGDM (3.36 fmol/ml (CI 3.09-3.63)), iGDM (3.82 fmol/ml (CI 3.53-4.11)) and the lowest ones were in the control group (2.54 fmol/ ml (CI 2.32-2.77)) (p<0.001). There was a positive correlation between ET-1 and glucose levels (r=0.45-0.57; p<0.05). Estimation of the level of sICAM-1 in the pregnant women from the study groups showed the highest values in those with carbohydrate metabolic disturbance and the lowest ones in those with preeclampsia. However, there were no significant intergroup differences in the levels of intercellular adhesion molecules. Conclusion. The pregnant women with GDM have higher plasma endothelin-1 levels. This level depends on the degree of diabetes compensation and takes the highest values in the patients with iGDM. In this connection, this contingent of women is at high risk for preeclampsia, HELLP syndrome, and fetal hypoxia. Timely detection of GDM, pathogenetic prevention, and therapy for preeclampsia will aid in reducing poor perinatal outcomes.

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About the authors

R. V KAPUSTIN

D.O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences

Email: Kapustin.Roman@gmail.com
Saint Petersburg, Russia

O. N ARZHANOVA

D.O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences; Saint Petersburg State University

Email: arjanova_olga@mail.ru
Department of Obstetrics, Gynecology and Reproductology, Faculty of Medicine Saint Petersburg, Russia

D. I SOKOLOV

D.O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences

Saint Petersburg, Russia

S. V CHEPANOV

D.O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences

Saint Petersburg, Russia

S. A SELKOV

D.O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences

Email: selkovsa@mail.ru
Saint Petersburg, Russia

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