CYTOKINE GENE POLYMORPHISM DURING TERM LABOR AND PROLONGED PREGNANCY


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. To study the role of cytokine gene polymorphism in term labor and prolonged pregnancy. Subject and methods. One hundred and eleven patients with term (n=87) or delayed (n=24) labor were examined. Polymerase chain reaction and melting curve analysis were used to study 10 cytokine gene polymorphic loci. Results. The women with term or delayed labor showed no significant differences in the allelic and genotyping distribution of the following polymorphisms: IL12: B -1188 C>A, IL18: -137 G>C, IL10: -592 А>C, VeGfA: 936 C>T, and -634 G>C, and IL1 gene family (IL1B: -31 T>C, IL1R1: -15858 C>T, and IL1RN: -390 T>C). The presence of -174 G>C IL-6 polymorphism was associated with the increased risk of delayed labor (OR = 4.9 (1.4 - 17.4); р = 0.004). The G -> A substitution at position -308 of the TNF gene was more common in the women who gave birth at term. The combination of IL-6-174 G>C and TNF-308G/G gene polymorphisms was associated with a 7.2-fold increase in the risk of prolonged pregnancy. Conclusion. The onset of labor at term is associated with the gene polymorphism of anti-inflammatory cytokines determining the level of their synthesis and secretion. 1) The presence of IL-6-174 G/C polymorphism in a woman is associated with a twofold increase in the incidence of delayed labor whereas the homozygous genotype G/G is typical of patients with term delivery. 2) The G->A substitution at position -308 in the promoter region of the TNF gene is a predisposing factor of prolonged pregnancy. 3) The risk of prolonged pregnancy increases by 7.2 times if there is a combination of IL-6 -174C and TNF -308G/G gene polymorphisms.

全文:

受限制的访问

作者简介

V. RUMYANTSEVA

Acad. V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: valya-ru@yandex.ru

A. STRIZHAKOV

I.N. Sechenov First Moscow State Medical University

Email: mmainter@mmascience.ru

O. BAYEV

Acad. V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: metod_obsgyn@hotmail.com

A. DONNIKOV

Acad. V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru

M. RYBIN

I.N. Sechenov First Moscow State Medical University

Email: info@gkb7.mosgorzdrav.ru

G. SUKHIKH

Acad. V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_sukhikh@oparina4.ru

参考

  1. Greene M.F. Two hundred yars of progress in the practice of Mmdwifery. N. Engl. J. Med. 2012; 367: 1732-40.
  2. Сидорова И.С. Физиология и патология родовой деятельности: Учебное пособие. М.: МИА; 2006. 240 с.
  3. Кетлинский С.А., Симбирцев А.С. Цитокины. СПб.: Фолиант; 2008. 552 с.
  4. Friebe-Hoffmann U., Chiao J.P., Rauk P.N. Effect of IL-1beta and IL-6 on oxytocin secretion in human uterine smooth muscle cells. Am. J. Reprod. Immunol. 2001; 46(3): 226-31.
  5. Chen Y.P., Pfab T., Slowinski T., Richter C.M., Godes M., Hocher B. Impact of genetic variation of tumor necrosis factor-alpha on gestational hypertension. Chin. Med. J. (Engl.). 2006; 119(9): 719-24.
  6. Stonek F., Bentz E.K., Hafner E., Metzenbauer M., Philipp K., Hefler L.A., Tempfer C.B. A tumor necrosis factor-alpha promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1652 pregnant women. Reprod. Sci. 2007; 14(5): 425-9.
  7. Warren J.E., Nelson L.M., Stoddard G.J., Esplin M.S., Varner M.W., Silver R.M. Polymorphisms in the promoter region of the interleukin-10 (IL-10) gene in women with cervical insufficiency. Am. J. Obstet. Gynecol. 2009; 201(4):372; e1-5. doi: 10.1016/j.ajog.2009.05.022.
  8. Moura E., Mattar R., de Souza E., Torloni M.R., Gongalves-Primo A., Daher S. Inflammatory cytokine gene polymorphisms and spontaneous preterm birth. J. Reprod. Immunol. 2009; 80(1-2): 115-21. doi: 10.1016/j.jri.2008. 11.007. 9.
  9. Yilmaz Y., Verdi H., Taneri A., Yazici A.C., Ecevit A.N., Karakaş N.M. Maternal-fetal proinflammatory cytokine gene polymorphism and preterm birth. DNA Cell Biol. 2012; 31(1): 92-7. doi: 10.1089/dna.2010.1169.
  10. Simhan H.N., Krohn M.A., Roberts J.M., Zeevi A., Caritis S.N. Interleukin-6 promoter -174 polymorphism and spontaneous preterm birth. Am. J. Obstet. Gynecol. 2003; 189(4): 915-8.
  11. Liang M., Wang X., Li J., Yang F., Fang Z., Wang L. et al. Association of combined maternal-fetal TNF-alpha gene G308A genotypes with preterm delivery: a gene-gene interaction study. J. Biomed. Biotechnol. 2010; 2010: 396184. doi: 10.1155/2010/396184. 9.
  12. Lu Z., Chen L., LiH., Zhao Y., Lin L. Effect ofthe polymorphism of tumor necrosis factor-alpha-308 G/A gene promoter on the susceptibility to ulcerative colitis: a meta-analysis. Digestion. 2008; 78(1): 44-51. doi: 10.1159/000158605.
  13. Gao J., Shan G., Sun B., Thompson P.J., Gao X. Association between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis. Thorax. 2006; 61(6): 466-71.
  14. Teuffel O., Ethier M.C., Beyene J., Sung L. Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis. Crit. Care Med. 2010; 38(1): 276-82. doi: 10.1097/CCM.0b013e3181b42af0.
  15. Huang S.L., Su C.H., Chang S.C. Tumor necrosis factor-alpha gene polymorphism in chronic bronchitis. Am. J. Respir. Crit. Care Med. 1997; 156(5): 1436-9.
  16. Кофиади И.А., Ребриков Д.В. Методы детекции однонуклеотидных полиморфизмов: аллель-специфичная ПЦР и гибридизация с олигонуклеотидной пробой. Генетика. 2006; 42(1): 22-32.
  17. Lyon E. Mutation detection using fluorescent hybridization probes and melting curve analysis. Expert Rev. Mol. Diagn. 2001; 1(1): 92-101.
  18. Стрижаков А.Н., Игнатко И.В., Тимохина Е.В., Рыбин М.В. Переношенная беременность. М.: Династия; 2006. 96 с.
  19. Чернуха Е.А. Переношенная и пролонгированная беременность. М.: ГЭОТАР-Медиа; 2007. 208 с.
  20. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J. Clin. Invest. 1998; 102(7): 1369-76.
  21. Pu J., Zeng W.Y. Gene polymorphism of tumor necrosis factor-alpha promoter region in -308 site and premature births in Chinese Han populations. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007; 38(6): 84-6, 1036.
  22. Menon R., Merialdi M., Betran A.P., Dolan S., Jiang L., Fortunato S., Williams S. Analysis of association between maternal tumor necrosis factor-alpha promoter polymorphism (-308), tumor necrosis factor concentration, and preterm birth. Am. J. Obstet. Gynecol. 2006; 195(5): 1240-8.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2013