A CASE OF A COMBINATION OF LOW-QUALITY OOCYTES AND UTERINE AND VAGINAL MALFORMATIONS IN A PATIENT WITH NORMAL OVARIAN MORPHOFUNCTIONAL PARAMETERS
- Authors: ABDULMEDZHIDOVA A.G1, ZVEREVA S.A1, NADYROVA N.O1
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Affiliations:
- OAO Meditsina Clinic, Moscow
- Issue: No 4 (2013)
- Pages: 80-83
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/246982
- ID: 246982
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Abstract
The data available in the literature on the cause and duration of a negative impact on oocytes and sperm, which induce future embryo fragmentation, are extremely discrepant. The given paper describes a clinical case. Case. Four in vitro fertilization (IVF) programs were implemented in Patient N. aged 36 years. Examination established that uterine and vaginal malformations were the only abnormality. Superovulation was induced using different gonadotropins in combination with gonadotropin-releasing hormone agonists and antagonists. In the four IVF programs, the average of 8.2±2.1 oocytes was obtained from the patient. Of them, fertilization and fragmentation were observed in an average of 7.0±1.8 oocytes and 6.7±1.5 embryos, respectively. However, all the cases exhibited marked embryo fragmentation (from 30 to 100%) with the first cleavage division. The patient was transferred in three embryos on day 3 with the minimal (30%) level of fragmentation. Two of the four IVF programs failed; the other two resulted in ectopic pregnancy and non-developing pregnancy at 6-7 weeks, respectively. Conclusion. Taking into account the fact that the formation of a pool of primary germ cells and the development of internal genital organs occur before day 32 of embryogenesis, the negative impact on the embryo during this period may give rise to a combination of low-quality oocytes and uterine and vaginal malformations. The given case report suggests that defective oocytes should be expected in patients with uterine and vaginal malformations.
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About the authors
A. G ABDULMEDZHIDOVA
OAO Meditsina Clinic, Moscow
Email: anisat2011@gmail.com
S. A ZVEREVA
OAO Meditsina Clinic, Moscow
Email: zvereva2010@mail.ru
N. O NADYROVA
OAO Meditsina Clinic, Moscow
Email: nno55@mail.ru
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