PAPILLOMAVIRUS INFECTION CAUSED BY HUMAN PAPILLOMAVIRUS TYPES 52 AND 58 AND ITS ROLE IN THE DEVELOPMENT OF CERVICAL INTRAEPITHELIAL NEOPLASIAS
- Authors: BESTAYEVA N.V1, NAZAROVA N.M1, PRILEPSKAYA V.N1, TROFIMOV D.Y.1, BURMENSKAYA O.V1, PAVLOVICH S.V1
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Issue: No 7 (2013)
- Pages: 45-50
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247009
- ID: 247009
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Abstract
Objective. To study the prevalence and role of different human papillomavirus (HPV) types, including HPV 52 and 58, in the development of cervical intraepithelial neoplasia (CIN) and cancer of the cervix uteri (CCU). Subject and methods. 548 women aged from 18 to 60 years with cervical pathology were examined. A study group consisted of 383 HPV-positive women. Clinical, anamnestic, gynecologic, molecular biological, and morphological studies and extended colposcopy were used. Results. The most common HPV types were 16, 58, 31, 52, 33, and 44(55). HPV 52 and 58 were more frequently found in women younger than 35 years (88%). Cytological examination revealed NILM in 169 (44.1%) patients, АSCUS in 16 (4.2%), LSIL in 82 (21.4%), HSIL in 99 (25.8%), and CCU in 17 (4.4%). HPV 52 and 58 were detected in 22(13%) women with HILM, in 1 (6.2%) with АSCUS, in 20(24.4%) with LSIL, in 25(25.2%) with HSIL, and in 2 (11.7%) with CCU. The HSIL and CCU groups displayed a significant increase in viral load as compared to the HILM group. Conclusion. HPV 52 and 58 have turned out to be more common than the previously presented data; they are a cause of abnormal cytology in 22.4% of the patients. The magnitude of viral load is associated with the degree of cervical lesion; however, it cannot be used as the only indicator of the unfavorable course of HPV infection.
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About the authors
N. V BESTAYEVA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: nonnabestaeva@mail.ru
N. M NAZAROVA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: grab2@yandex.ru
V. N PRILEPSKAYA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: VPrilepskaya@mail.ru
D. YU TROFIMOV
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: d.troflmov@dna-tech.ru
O. V BURMENSKAYA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: o_bourmenskaya@oparina4.ru
S. V PAVLOVICH
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: s_pavlovich@oparina4.ru
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