ROLE OF MARKERS FOR TROPHOBLAST INVASION IN THE DEVELOPMENT OF PREECLAMPSIA AND TUMOR PROGRESSION


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Abstract

Preeclampsia is one of the most severe pregnancy complications, leading to maternal and perinatal morbidity and mortality. In recent years, there has have been an increase in the number of investigations of the association of preeclampsia with the processes of trophoblast invasion. There is also evidence that the processes of trophoblast invasion and tumor progression are similar. The review gives the last decade’s data on impaired trophoblast invasion processes and their impact on the occurrence of complications, such as preeclampsia, as well as the possibility of its timely diagnosis and pathogenetic treatment.

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About the authors

D. N VODNEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_selivanova@oparina4.ru

R. G SHMAKOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mdshmakov@mail.ru

A. I SHCHEGOLEV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: ashegolev@oparina4.ru

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