NEW POSSIBILITIES FOR THE DIAGNOSIS AND TREATMENT OF HPV-ASSOCIATED PREINVASIVE NEOPLASIAS AT A REPRODUCTIVE AGE


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Abstract

Objective. To enhance the efficiency of treatment for cervical intraepithelial neoplasia (CIN) in reproductive-aged women, by including high-speed modified optical coherence tomography (OCT) and using photodynamic therapy (PDT) in the diagnostic process if there are signs of human papillomavirus (HPV) infection at the resection margin after electric cervical conization with a sail electrode. Subject and methods. The preoperative examination of 32 patients with CINII-III involved high-speed modified OCT colposcopy to determine the borders of a pathological focus. PDT was performed when the signs of HPV infection and CIN I plus were detected. Results. Fifteen patients were histologically found to have HPV-associated epithelial changes at the resection margin, which was an indication for PDT. This was OCT predictable in 80% of cases. Complete HPV elimination was achieved in 12 women after PDT. Conclusion. OCT colposcopy optimizes the planning of a resection zone. PDT has been ascertained to be effective after cervical sparing surgery.

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About the authors

T. S KACHALINA

Nizhny Novgorod State Medical Academy

S.S. Dobrotin Department of Obstetrics and Gynecology

N. M SHAKHOVA

Nizhny Novgorod State Medical Academy

S.S. Dobrotin Department of Obstetrics and Gynecology

O. V KACHALINA

Nizhny Novgorod State Medical Academy

Email: yander24@bk.ru
S.S. Dobrotin Department of Obstetrics and Gynecology

E. V GREBENKINA

Nizhny Novgorod State Medical Academy

Email: gelena1980@mail.ru
S.S. Dobrotin Department of Obstetrics and Gynecology

S. V GAMAYUNOV

Nizhny Novgorod State Medical Academy

Email: Gamajnovs@mail.ru
S.S. Dobrotin Department of Obstetrics and Gynecology

D. D ELISEEVA

Nizhny Novgorod State Medical Academy

S.S. Dobrotin Department of Obstetrics and Gynecology

G. A MIKAILOVA

Nizhny Novgorod State Medical Academy

Email: gulja260290@rambler.ru
S.S. Dobrotin Department of Obstetrics and Gynecology

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