Relationship between HPV-associated genital and anal neoplasias, their diagnosis and treatment


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Abstract

The review considers the role of HPV in the development of genital and anal neoplasias. It gives an update on the prevalence of anal intraepithelial neoplasia (AIN), anal HPV infection among risk group (CIN, VIN, VaIN) women. The risk factors of anal and genital neoplasias and methods for their diagnosis are considered. The literature on the importance of developing AIN screening in patients with CIN, VIN, or VaIN is analyzed.

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About the authors

V. N Prilepskaya

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: VPrilepskaya@mail.ru
MD, PhD, Professor, Deputy Director for Science

N. M Nazarova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: grab2@yandex.ru
MD, PhD, Senior Reserch Fellow

L. A Sulamanidze

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: lika.sulamanidze@gmail.com
PhD student

D. Yu Trofimov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d.troflmov@dna-tech.ru
MD, PhD, Molecular-genetic Laboratory Chief

V. D Chuprynin

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_chuprynin@oparina4.ru
PhD, Head of the Department of General Surgery

References

  1. Johnson L.G., Madeleine M.M., Newcomer L.M., Schwartz S.M., Daling J.R. Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973-2000. Cancer. 2004; 101(2): 281-8.
  2. De Sanjose S., Quint W.G., Alemany L., Geraets D.T., Klaustermeier J.E., Lloveras B. et al.; Retrospective International Survey and HPV Time Trends Study Group. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol. 2010; 11(11):1048-56.
  3. Scully R., Bonfiglio T. WHO Classification of tumors of the female genital tract. New York; 1994.
  4. http://www.asccp.org/Practice-Management/LAST-Project/LAST-Consensus-Recommendations-and-Resources
  5. Hoots B.E., Palefsky J.M., Pimenta J.M., Smith J.S. Human papillomavirus type distribution in anal cancer and anal intraepithelial lesions. Int. J. Cancer. 2009; 124(10): 2375-83.
  6. De Pokomandy A., Rouleau D., Ghattas G., Vézina S., Coté P., Macleod J. et al.; HIPVIRG Study Group. Prevalence, clearance, and incidence of anal human papillomavirus infection in HIV-infected men: the HIPVIRG cohort study. J. Infect. Dis. 2009; 199(7): 965-73.
  7. Park I.U., Palefsky J.M. Evaluation and management of anal intraepithelial neoplasia in HIV-negative and HIV-positive men who have sex with men. Curr. Infect. Dis. Rep. 2010; 12(2): 126-33.
  8. Palefsky J.M., Holly E.A., Ralston M.L., Jay N. Prevalence and risk factors for human papillomavirus infection on the anal canal in human immunodeficiency virus HIV-positive and HIV-negative homosexual men. J. Infect. Dis. 1998; 177(2): 361-7.
  9. Palefsky J.M. Anal human papillomavirus infection and anal cancer in HIV-positive individuals: an emerging problem. AIDS. 1994; 8(3): 283-95.
  10. Solomon D., Davey D., Kurman R., Moriarty A., O’Connor D., Prey M. et al.; Bethesda 2001 Workshop. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA. 2002; 287(16): 2114-9.
  11. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer. 2010; 127(12): 2893-917.
  12. Palefsky J.M., Holly E.A., Hogeboom C.J., Ralston M.L., DaCosta M.M., Botts R. et al. Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1998; 17(4): 314-9.
  13. Melbye M., Spr0gel P. Aetiological parallel between anal cancer and cervical cancer. Lancet. 1991; 338(8768): 657-9.
  14. Palefsky J.M., Barrasso R. HPV infection and disease in men. Obstet. Gynecol. Clin. North Am. 1996; 23(4): 895-916.
  15. Palefsky J.M. Cutaneous and genital HPV-associated lesions in HIV-infected patients. Clin. Dermatol. 1997; 15(3): 439-47.
  16. Palefsky J.M., Holly E.A., Ralston M.L., Arthur S.P., Jay N., Berry J.M. et al. Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1998; 17(4): 320-6.
  17. Palefsky J.M., Shiboski S., Moss A. Risk factors for anal human papillomavirus infection and anal cytologic abnormalities in HIV-positive and HIV-negative homosexual men. J. Acquir. Immune Defic. Syndr. 1994; 7(6): 599-66.
  18. Moscicki A.B., Hills N.K., Shiboski S., Darragh T.M., Jay N., Powell K. et al. Risk factors for abnormal anal cytology in young heterosexual women. Cancer Epidemiol. Biomarkers Prev. 1999; 8(2): 173-8.
  19. Palefsky J.M., Holly E.A., Ralston M.L., Arthur S.P., Hogeboom C.J., Darragh T.M. Anal cytological abnormalities and anal HPV infection in men with Centers for Disease Control group IV HIV disease. Genitourin. Med. 1997; 73(3): 174-80.
  20. Kiviat N.B., Critchlow C.W., Holmes K.K., Kuypers J., Sayer J., Dunphy C. et al. Association of anal dysplasia and human papillomavirus with immunosuppression and HIV infection among homosexual men. AIDS. 1993; 7(1): 43-9.
  21. Palefsky J.M. Anal squamous intraepithelial lesions in human immunodeficiency virus-positive men and women. Semin. Oncol. 2000; 27(4): 471-9.
  22. Park I.U., Ogilvie J.W. Jr., Anderson K.E., Li Z., Darrah L., Madoff R., Downs L. Jr. Anal human papillomavirus infection and abnormal anal cytology in women with genital neoplasia. Gynecol. Oncol. 2009; 114(3): 399-403.
  23. Mayeaux E.J.Jr., Cox J.T. Modern colposcopy. Texbook & atlas. 3rd ed. Philadelphia: Wolters Kluwer, Lippincott Williams & Wilkins; 2011.
  24. Chin-Hong P.V., Vittinghoff E., Cranston R.D., Buchbinder S., Cohen D., Colfax G. et al. Age-specific prevalence of anal human papillomavirus infection in HIV-negative sexually active men who have sex with men: the EXPLORE study. J. Infect. Dis. 2004; 190(12): 2070-6.
  25. Machalek D.A., Poynten M., Jin F., Fairley C.K., Farnsworth A., Garland S.M. et al. Anal human papillomavirus infection and assoicated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis. Lancet Oncol. 2012; 13(5): 487-500.
  26. Holly E.A., Ralston M.L., Darragh TM., Greenblatt R.M., Jay N., Palefsky J.M. Prevalence and risk factors for anal squamous intraepithelial lesions in women. J. Natl. Cancer Inst. 2001; 93(11): 843-9.
  27. Chiao E.Y., Giordano T.P., Palefsky J.M., Tyring S., El Serag H. Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review. Clin. Infect. Dis. 2006; 43(2): 223-33.
  28. Darragh T.M., Birdsong G.G., Luff R.D., Davey D.D. Anal-rectal cytology. In: Solomon D., Nayar R., eds. The Bethesda System for reporting cervical cytology: definitions, criteria and explanatory notes. 2nd ed. New York: Springer; 2004: 169-75.
  29. Darragh T.M. Anal cytology. In: Wilbur D.C., Henry M.R., eds. College of American pathologists practical guide to gynecologic cytopathology: morphology, management and molecular methods. Northfield, IL: CAP Press; 2008: 177-81.
  30. Salit L.E., Lytwyn A., Rabound J., Sano M., Chong S., Diong C. et al. The role of cytology (Pap tests) and human papillomavirus testing in anal cancer screening. AIDS. 2010; 24(9): 1307-13.
  31. Bean S.M., Chhieng D.C. Anal-rectal cytology: a review. Diagn. Cytopathol. 2010; 38(7): 538-46.
  32. Santoso J.T., Long M., Crigger M., Wan J.Y., Haefner H.K. Anal intraepithelial neoplasia in women with genital intraepithelial neoplasia. Obstet. Gynecol. 2010; 116(3): 578-8.
  33. Davey E., Barratt A., Irwig L., Chan S.F., Macaskill P., Mannes P., Saville A.M. Effect of study design and quality on unsatisfactory rates, cytology classifications, and accuracy in liquid-based versus conventional cervical cytology: a systematic review. Lancet. 2006; 376(9505): 122-32.
  34. Chin-Hong P.V., Palefsky J.M. Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus. Clin. Infect. Dis. 2002; 35(9): 1127-34.
  35. Singh J.C., Kuohung V., Palefsky J.M. Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV-positive and HIV-negative men who have sex with men. J. Acquir. Immune Defic. Syndr. 2009; 52(4): 474-9.
  36. Richel O., Wieland U., de Vries H.J., Brockmeyer N.H., van Noesel C., Potthoff A. et al. Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men. Br. J. Dermatol. 2010; 163(6): 1301-7.
  37. Kreuter A., Potthoff A., Brockmeyer N.H., Gambichler T., Stücker M., Altmeyer P. et al. Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men. J. Invest. Dermatol. 2008; 128(8): 2078-83.
  38. Fox P.A., Nathan M., Francis N., Singh N., Weir J., Dixon G. et al. A doubleblind, randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high-grade anal intraepithelial neoplasia in HIV-positive MSM on HAART, with long-term follow-up data including the use of open-label imiquimod. AIDS. 2010; 24(15): 2331-5.
  39. Palefsky J.M., Cranston R.D., Dezube B.J., Ross M.E. Anal intraepithelial neoplasia: diagnosis, screening, prevention, and treatment. 2012. Cr. опубл. на UpToDate онлайн (консультативный мед. форум в США).
  40. Stier E.A., Goldstone S.E., Berry J.M., Panther L.A., Jay N., Krown S.E. et al. Infrared coagulator treatment of high-grade anal dysplasia in HIV-infected individuals: an AIDS malignancy consortium pilot study. J. Acquir. Immune Defic. Syndr. 2008; 47(1): 56-61.
  41. Goldstone S.E., Hundert J.S., Huyett J.W. Infrared coagulator ablation of highgrade anal squamous intraepithelial lesions in HIV-negative males who have sex with males. Dis. Colon Rectum. 2007; 50(5): 565-75.
  42. Cranston R.D., Hirschowitz S.L., Cortina G., Moe A.A. A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men. Int. J. STD AIDS. 2008; 19(2): 118-20.
  43. Pineda C.E., Berry J.M., Jay N., Palefsky J.M., Welton M.L. High-resolution anoscopy targeted surgical destruction of anal high-grade squamous intraepithelial lesions: a ten-year experience. Dis. Colon Rectum. 2008; 51(6): 82-35; discussion 835-7.
  44. Weis S.E., Vecino I., Pogoda J.M., Susa J.S. Treatment of high-grade anal intraepithelial neoplasia with infrared coagulation in a primary care population of HIV-infected men and women. Dis. Colon Rectum. 2012; 55(12): 1236-43.

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