MOLECULAR GENETIC MARKERS AS PROGNOSTIC FACTORS OF AN OVARIAN RESPONSE IN ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS


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Abstract

The prevalence of infertility among reproductive-aged married couples is on the rise, amounting to as high as 15%. Difficulties in predicting an ovarian response to superovulation induced by gonadotropins are one of the most intractable problems in the in vitro fertilization (IVF) treatment of the patients. Genetic variability is an important factor to determine the ovarian response to superovulation in an IVF program. Interpretation of genetic mechanisms for regulation of the reproductive system contributes to the development of a personalized approach to treating infertility in reproductive medicine. Impressive progress has been made in searching for the genes associated with ovarian function since a map of the human genome was created. Investigations of gene associations revealed a number of gene polymorphisms (single nucleotide polymorphism (SNP) that affected the synthesis and activity of hormones, risk factors, etc. and are thus involved in the ovarian response. This may explain the individual variability encountered in the response of ovaries to stimulation of their function. Genetic polymorphisms may become the most important predictive factors of an ovarian response. The role of genes, such as FSHR, ESR1, ESR2, LHB, LHCGR, AMH, AMHR2, BMP15, etc., is of considerable interest in predicting the ovarian response in assisted reproductive technology (ART) programs. The objective of this review is to systematically analyze the data available in the current literature on molecular genetic factors that influence an ovarian response in the ART programs.

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About the authors

Inna Vladimirovna VLADIMIROVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: i_teterina@oparina4.ru
Postgraduate of Department of Assisted Technology in Infertility Treatment 117997, Russia, Moscow, Ac. Oparina str. 4

Elena A. KALININA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
MD, Head, Department of Assisted Technology in Infertility Treatment 117997, Russia, Moscow, Ac. Oparina str. 4

Andrey E. DONNIKOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
scientist of the laboratory of molecular genetics methods 117997, Russia, Moscow, Ac. Oparina str. 4

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