Postmenopausal structural and molecular rearrangements in the polyps and adjacent endometrium: processes of proliferation, neoangiogenesis, aging, and apoptosis


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Abstract

Objective. To morphologically examine the processes of growth, neoangiogenesis, aging, and apoptosis in the polyps and their adjacent endometrium in postmenopausal women. Subject and methods. Forty-six women were examined. Group 1 included 11 patients with adenomatous polyps (AP); Group 2 comprised 17patients with fibroglandular polyps (FGP); Group 3 consisted of 18 patients with the atrophic endometrium and no evidence of polyps (a control group). The expression of the markers of Ki-67, VEGF, ApoCas, PTEN, and p16 INK4a was assessed in the epithelial and stromal cells of a polyp and its adjacent endometrium and in those of the control endometrium. Results. The AP epithelium has high proliferation, low apoptosis, and, on occasion, changes characteristic of malignant cell transformation (PTEN loss, p16 INK4a and Ki-67 coexpression). There is a significant difference between the surrounding AP and GFP endometrium that in turn distinct from the control endometrium. Conclusion. AP and GGP have different mechanisms of pathogenesis and differ not only in their morphological structure, but also in the expression of the markers of growth, neoangiogenesis, aging, and apoptosis in their stromal and epithelial components. The findings should be recommended to improve a differential approach to their treatment and to decide on the volume of endometrial destruction in this pathology.

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About the authors

E. A Kogan

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kogan@oparina4.ru
MD. Prof. I Pathology Department

Sh. N Sattarov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: docshuhrat@yahoo.com
postgraduate

S. E Sarkisov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: 734l497@mail.ru
MD, professor, Innovational Department of minimally invasive technologies in gynecology

N. M Faizullina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_faizullina@oparina4.ru
Senior Research Fellow, I Pathology Department

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