PATHOMORPHOLOGICAL CHARACTERISTICS OF BRAIN LESION IN SEVERE PREECLAMPSIA AND ECLAMPSIA


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Abstract

Objective. To study the pathomorphological and immunohistochemical lesions of the brain in patients who died from severe forms of preeclampsia and eclampsia. Subject and methods. Retrospective analysis of 8 histories of pregnancy, labor, and delivery and postmortem protocols, as well as immunohistochemical examination of brain tissue to visualize neurospecific enolase were made in patients who had died from severe preeclampsia/eclampsia (a study group). A comparison group included 3 patients who had died from other causes. Results. The pathological changes in the women who died from severe forms of preeclampsia/eclampsia are suggestive of severe ischemic encephalopathy with generalized vascular brain damage (to the point of total desquamation of endotheliocytes), including the vessels of the blood-brain barrier. Conclusion. The cause of most fatal complications in preeclampsia and eclampsia was inadequate cerebral flow autoregulation with loss of a regulatory role of the endothelium and breakthrough in the blood-brain barrier.

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About the authors

Iraida Stepanovna SIDOROVA

I.M. Sechenov First Moscow State Medical University

MD, Professor, RAMS Corresponding Member, Honoured Scientist of the Russian Federation Ul. Trubetskaya, 8, build. 2. 119991 Moscow, Russia

Andrey Petrovich MILOVANOV

Research Institute of Human Morphology, Russian Academy of Medical Sciences

MD, Professor, Corresponding Member of the Russian Academy of Natural Sciences, Honoured Scientist of the Russian Federation 3, Tsyurupa St., 117418, Moscow, Russia

Natalya Aleksandrovna NIKITINA

I.M. Sechenov First Moscow State Medical University

Email: natnikitina@list.ru
Candidate of Medical Sciences, Associate Professor of the Chair of Obstetrics and Gynaecology № l Ul. Trubetskaya, 8, build. 2. 119991 Moscow, Russia

Ainur Abilovna RZAEVA

I.M. Sechenov First Moscow State Medical University

Email: Rzayeval978@mail.ru
tgraduate Student of the Chair of Obstetrics and Gynaecology № l, Therapeutic Faculty Ul. Trubetskaya, 8, build. 2. 119991 Moscow, Russia

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