FREE EMBRYONIC DNA IN THE PREDICTION OF PREGNANCY OUTCOME IN OBSTETRIC PATHOLOGY


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The review sets forth current views on the role of free embryonic DNA (feDNA) in the prediction of pregnancy complications and outcomes. It describes the procedures that could determine feDNA in the blood of pregnant women regardless of the sex and rhesus factor of a fetus. The trial data suggesting that there is an association between elevated feDNA levels in spontaneous miscarriage, preterm births, preeclampsia, and fetal growth retardation are outlined. There are also results of predicting complications and diagnosing aneuploidies in the noninvasive fashion. The possibilities of clinically using these techniques in both risk-group pregnant women and as screening tools are described.

Full Text

Restricted Access

About the authors

N. G PARSADANYAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nnnpars@mail.ru
Graduate student, Department of Pregnancy Loss Prevention and Therapy 117997, Russia, Moscow, Ac. Oparina Str. 4

E. S SHUBINA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_shubina@oparina4.ru
Graduate student, laboratory of molecular genetic methods 117997, Russia, Moscow, Ac. Oparina Str. 4

D. Yu TROFIMOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_troflmov@oparina4.ru
Ph.D. in medical sciences, Head of Laboratory of molecular genetic methods 117997, Russia, Moscow, Ac. Oparina Str. 4

N. K TETRUASHVILI

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy 117997, Russia, Moscow, Ac. Oparina Str. 4

References

  1. Lo Y.M., Corbetta N., Chamberlain P.F., Rai V., Sargent I.L., Redman C.W., Wainscoat J.S. Presence of fetal DNA in maternal plasma and serum. Lancet. 1997; 350(9076): 485-7.
  2. Zhong X.Y., Laivuori H., Livingston J.C., Ylikorkala O., Sibai B.M., Holzgreve W., Hahn S. Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. Am. J. Obstet. Gynecol. 2001; 184(3): 414-9.
  3. Hill M., Taffinder S., Chitty L.S., Morris S. Incremental cost of non-invasive prenatal diagnosis versus invasive prenatal diagnosis of fetal sex in England. Prenat. Diagn. 2011; 31(3): 276-73.
  4. Ishihara N., Matsuo H., Murakoshi H., Laoag-Fernandez J.B., Samoto T., Maruo T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsiaor intrauterine growth retardation. Am. J. Obstet. Gynecol. 2002; 186(1): 158-66.
  5. Leung T.N., Lau T.K., Chung T.K. Thalassaemia screening in pregnancy. Curr. Opin. Obstet. Gynecol. 2005; 17(2): 129-34.
  6. Masuzaki H., Miura K., Yoshiura K.I., Yoshimura S., Niikawa N., Ishimaru T. Detection of cell free placental DNA in maternal plasma: direct evidence from three cases of confined placental mosaicism. J. Med. Genet. 2004; 41(4): 289-92.
  7. Costa J.M., Benachi A., Gautier E. New strategy for prenatal diagnosis of X-linked disorders. N. Engl. J. Med. 2002; 346(19): 1502.
  8. Hall A., Bostanci A., Wright C.F Non-invasive prenatal diagnosis using cell-free fetal DNA technology: applications and implications. Public Health Genomics. 2010; 13(4): 246-55.
  9. Chiu R.W., Lau T.K., Cheung P.T., Gong Z.Q., Leung T.N., Lo Y.M. Noninvasive prenatal exclusion of congenital adrenal hyperplasia by maternal plasma analysis: a feasibility study. Clin. Chem. 2002; 48(5): 778-80.
  10. Wright C.F., Burton H. The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis. Hum. Reprod. Update. 2009; 15(1): 139-51.
  11. Nygren A.O., Dean J., Jensen T.J., Kruse S., Kwong W., van den Boom D., Ehrich M. Quantification of fetal DNA by use of methylation-based DNA discrimination. Clin. Chem. 2010; 56(10): 1627-35.
  12. Zhao F., Wang J., Liu R., Yang J., Cui K., Wu Y. et al. Quantification and application of the placental epigenetic signature of the RASSF1A gene in maternal plasma. Prenat. Diagn. 2010; 30(8): 778-82.
  13. Pertl B., Sekizawa A., Samura O., Orescovic I., Rahaim P.T., Bianchi D.W. Detection of male and female fetal DNA in maternal plasma by multiplex fluorescent polymerase chain reaction amplification of short tandem repeats. Hum. Genet. 2000; 106(1): 45-9.
  14. Lo Y.M., Leung T.N., Tein M.S., Sargent I.L., Zhang J., Lau T.K. et al. Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia. Clin. Chem. 1999; 45(2): 184-8.
  15. Rusterholz C., Messerli M., Hoesli I., Hahn S. Placental microparticles, DNA, and RNA in preeclampsia. Hypertens. Pregnancy. 2011; 30: 364-75.
  16. Farina A., LeShane E.S., Romero R., Gomez R., Chaiworapongsa T., Rizzo N., Bianchi D.W. High levels of fetal cell-free DNA in maternal serum: a risk factor for spontaneous preterm delivery. Am. J. Obstet. Gynecol. 2005; 193(2): 421-5.
  17. Sekizawa A., Jimbo M., Saito H., Iwasaki M., Sugito Y., Yukimoto Y. et al. Increased cell-free fetal DNA in plasma of two women with invasive placenta. Clin. Chem. 2002; 48(2): 353-4.
  18. Al Nakib M., Desbrière R., Bonello N., Bretelle F., Boubli L., Gabert J., Levy-Mozziconacci A. Total and fetal cell-free DNA analysis in maternal blood as markers of placental insufficiency in intrauterine growth restriction. Fetal Diagn. Ther. 2009; 26(1): 24-8.
  19. Alberry M.S., Maddocks D.G., Hadi M.A., Metawi H., Hunt L.P., Abdel-Fattah S.A. et al. Quantification of cell free fetal DNA in maternal plasma in normal pregnancies and in pregnancies with placental dysfunction. Am. J. Obstet. Gynecol. 2009; 200: 98. e1-6.
  20. Jakobsen T.R., Clausen F.B., Rode L., Dziegiel M.H., Tabor A. High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery. Prenat. Diagn. 2012; 32(9): 840-5.
  21. Lim J.H., Kim M.H., Han Y.J., Lee da E., Park S.Y., Han J.Y. et al. Cell-free fetal DNA and cell-free total DNA levels in spontaneous abortion with fetal chromosomal aneuploidy. PLoS One. 2013; 8(2): e56787.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2014 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies