The receptor status of endometrial polyps in postmenopausal women


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To study the expression of estrogen and progesterone receptors (ER and PR) in the epithelial and stromal cells of endometrial polyps and their adjacent endometrium in postmenopausal women. Subject and methods. Clinical and laboratory studies were performed in 96 patients with endometrial polyps. Three groups were selected for immunohistochemical examination. Group 1 comprised 11 patients with adenomatous polyps; Group 2 consisted of 17 patients with fibroglandular polyps; a comparison group included 18patients with the non-polypoid atrophic endometrium. An immunohistochemical technique was used to estimate ER and PR expressions in the epithelial and stromal cells of a polyp and its adjacent endometrium and those of the control endometrium. Results. There were higher ER and PR expressions in the epithelium and stroma of endometrial polyps than in those of the adjacent endometrium. Adenomatous and fibroglandular endometrial polyps were found to differ not only in their morphological structure, but also in the expression of sex hormone receptors in their stromal and epithelial components. There was also a substantial difference between the endometria surrounding each of these histotypes of polyps, which are in turn distinct from the control endometrium in their higher ER and PR expressions. Conclusion. The higher steroid receptor expression in the epithelia of polyps than that in the adjacent endometrium suggests that these steroid hormone structures are more highly sensitive, which determines the chance of their increase with the low local estrogen levels and in the surrounding atrophic endometrium. An understanding of the role of steroid receptors in the pathogenesis of different types of polyps may improve a differentiated approach when choosing treatment policy and the volume of endometrial destruction in this pathology.

Full Text

Restricted Access

About the authors

Yevgeniya Altarovna Kogan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: koganevg@gmail.com
PhD. Prof. I Pathology Department

Shukhrat Nusratillaevich Sattarov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: docshuhrat@yahoo.com
postgraduate

Sergey Eduardovich Sarkisov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: 7341497@mail.ru
PhD, professor, Innovational Department of minimally invasive technologies in gynecology

Marina Alexandrovna Boiko

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bma555@bk.ru
postgraduate

Irina Oganesovna Mamikonyan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: irulikjan@rambler.ru
postgraduate

References

  1. Бреусенко В.Г., Голова Ю.А., Каппушева Л.М., Мишиева О.И., Кирикова Ю.М., Цечоева Т.С. Современные подходы в лечении пролиферативных процессов эндометрия в постменопаузе. В кн.: Прилепская В.Н., ред. Клиническая гинекология. М.: МЕДпресс-информ; 2007: 315-23
  2. Хитрых О.В. Отдаленные результаты и оптимизация тактики лечения полипов эндометрия в постменопаузе: Автореф. дис. ... канд. мед. наук. М.; 2009
  3. Хужокова И.Н. Диагностическая и лечебная тактика при полипах эндометрия в постменопаузе: Автореф. дис. ... канд. мед. наук. М.; 2001
  4. Hassa H., Tekin B., Senses T., Kaya M., Karatas A. Are the site, diameter, and number of endometrial polyps related with symptomatology? Am. J. Obstet. Gynecol. 2006; 194(3): 718-21.
  5. Antunes A.Jr, Costa-Paiva L., Arthuso M., Costa J.V., Pinto-Neto A.M. Endometrial polyps in pre- and postmenopausal women: factors associated with malignancy. Maturitas. 2007; 57(4): 415-21.
  6. Newell S., Overton C. Postmenopausal bleeding should be referred urgently. Practitioner. 2012; 256(1749): 13-5, 2.
  7. American Association of Gynecologic Laparoscopists. AAGL practice report: practice guidelines for the diagnosis and management of endometrial polyps. J. Minim. Invasive Gynecol. 2012; 19(1): 3-10.
  8. Costa-Paiva L., Godoy C.E.Jr., Antunes A.Jr., Caseiro J.D., Arthuso M., Pinto-Neto A.M. Risk of malignancy in endometrial polyps in premenopausal and postmenopausal women according to clinicopathologic characteristics. Menopause. 2011; 18(12): 1278-82.
  9. Fletcher J.A., Pinkus J.L., Lage J.M., Morton C.C., Pinkus G.S. Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp. Genes Chromosomes Cancer. 1992; 5(3): 260-3.
  10. Dal Cin P., Vanni R., Marras S., Moerman P., Kools P., Andria M. et al. Four cytogenetic subgroups can be identified in endometrial polyps. Cancer Res. 1995; 55(7): 1565-8.
  11. Сметник В.П., Тумилович Л.Г. Неоперативная гинекология: Руководство для врачей. 3-е изд. М.: МИА; 2005. 632 с.
  12. Buckley C.H., Fox H. Biopsy pathology of the endometrium. 2nd ed. London: Hodder Arnold Publ.; 2002. 272 p.
  13. Dreisler E., Sorensen S.S., Lose G. Endometrial polyps and associated factors in Danish women aged 36-74 years. Am. J. Obstet. Gynecol. 2009; 200:147. e1-6.
  14. Biron-Shental T., Tepper R., Fishman A., Shapira J., Cohen I. Recurrent endometrial polyps in postmenopausal breast cancer patients on tamoxifen. Gynecol. Oncol. 2003; 90(2): 382-6.
  15. Cohen I. Endometrial polyps in pre-and postmenopausal women: factors associated with malignancy. Maturitas. 2008; 59(1): 99-100.
  16. Van den Bosch T., Van Schoubroeck D., Ameye L., De Brabanter J., Van Huffel S., Timmerman D. Ultrasound assessment of endometrial thickness and endometrial polyps in women on hormonal replacement therapy. Am. J. Obstet. Gynecol. 2003; 188: 1249-53.
  17. Koshiyama M., Yoshida M., Takemura M., Yura Y., Matsushita K., Hayashi M., et al. Immunohistochemical analysis of distribution of estrogen receptors and progesterone receptors in the postmenopausal endometrium. Acta Obstet. Gynecol. Scand. 1996; 75(8): 702-6.
  18. SantAna de Almeida E.C., Nogueira A.A., Candido dos Reis FJ., Zambelli Ramalho L.N., Zucoloto S. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women. Maturitas. 2004; 49(3): 229-33.
  19. Taylor L.J., Jackson T.L., Reid J.G., Duffy S.R. The differential expression of oestrogen receptors, progesterone receptors, Bcl-2 and Ki67 in endometrial polyps. Br. J. Obstet. Gynaecol. 2003; 110: 794-8.
  20. McCluggage W.G. Benign diseases of the endometrium. In: Kurman R.J., Ellenson L.H., Ronnett B.M., eds. Blaustein’s pathology of the female genital tract. 6th ed. New York: Springer-Verlag; 2011: 305-58.
  21. Савельева Г.М., Бреусенко В.Г., Каппушева Л.М. Гистероскопия. Атлас и руководство. М.: ГЭОТАР-Медиа; 2013. 248 с.//Savel’eva G.M., Breusenko V.G., Kappusheva L.M. Gisteroskopija. Atlas i rukovodstvo. M.: GJeOTAR-Media; 2013. 248 s.
  22. McClelland R.A., Wilson D., Leake R., Finlay P., Nicholson R.I. A multicentre study into the reliability of steroid receptor immunocytochemical assay quantification. British Quality Control Group. Eur. J. Cancer. 1991; 27(6): 711-5.
  23. Thijs I., Neven P., Van Hooff I., Tonglet R., Van Belle Y., De Muylder X., Vanderick G. Oestrogen and progesterone receptor expression in postmenopausal endometrial polyps and their surrounding endometrium. Eur. J. Cancer. 2000; 36(Suppl.4): 108-9.
  24. Belisdrio M.S., Vassallo J., Andrade L.A., Alvarenga M., Pinto G.A., Monteiro I.M. The expression of the hormone receptors in the endometrium and endometrial polyps in postmenopausal women and its relationship to body mass index. Maturitas. 2006; 53(1): 114-8.
  25. McTiernan A., Tworoger S.S., Ulrich C.M., Yasui Y., Irwin M.L., Rajan K.B. et al. Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. Cancer Res. 2004; 64(8): 2923-8.
  26. Reslova T., Tosner J., Resl M., Kugler R., Vavrova I. Endometrial polyps. A clinical study of 245 cases. Arch. Gynecol. Obstet. 1999; 262: 133-9.
  27. Arnold J.T., Kaufman D.G., Seppälä M., Lessey B.A. Endometrial stromal cells regulate epithelial cell growth in vitro: a new co-culture model. Hum. Reprod. 2001; 16(5): 836-45.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies