Mitochondrial dysfunction as one of the mechanisms of impaired reproductive function in obesity


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Abstract

The review gives data on the role of mitochondrial function in the oocytes and embryos in realizing the reproductive potential in obese women. Many publications have shown the lower therapeutic effectiveness of an in vitro fertilization program in overweight women than in normal weight ones, which is manifested in the reductions of the number of oocytes and the potential of embryos to implantation and further development and which is also accompanied by increased aneuploidy rates. The given data suggest that chronic oxidative stress in overweight women is associated with mitochondrial dysfunction and elevated blood levels of proinflammatory factors. Moreover, induction of chronic inflammation has a negative impact on the quality of oocytes and embryos, leading to impaired implantation and further increased risk of pregnancy termination.

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About the authors

V. K Gorshinova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: chiasma@mail.ru
Post-graduate student, Department of assistive technologies in infertility treatment 117997, Russia, Moscow, Ac. Oparina str. 4

D. V Tsvirkun

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: darunyat@gmail.com
PhD, Senior researcher, Mitochondrial medicine group 117997, Russia, Moscow, Ac. Oparina str. 4

N. V Desyatkova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Post-graduate student, Department of assistive technologies in infertility treatment 117997, Russia, Moscow, Ac. Oparina str. 4

M. Yu Vysokikh

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia; A.N. Belozersky Research Institute of Physicochemical Biology, M.V. Lomonosov Moscow State University

Email: m_vysokikh@oparina4.ru
PhD, Head of mitochondrial medicine research group; Head of aging molecular mechanisms group 117997, Russia, Moscow, Ac. Oparina str. 4

V. Yu Smolnikova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: veronika.smolnikova@mail.ru
PhD, Leading researcher, Department of assistive technologies in infertility treatment 117997, Russia, Moscow, Ac. Oparina str. 4

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