Role of polyunsaturated fatty acids in ensuring the health of a mother and her child


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Abstract

A proper diet is of great importance in preserving the health of a pregnant woman and in ensuring the full development of her future child. The use of vitamin-mineral complexes and biologically active food additives is a justified method to prevent pregnancy complications and negative perinatal outcomes when considering that the pattern of nutrition and the quality of foodstuffs do not provide the intake of essential micronutrients. Among the substances that are essential to life, omega-3 polyunsaturated fatty acids involved in the morphogenesis and normal function of tissues and organs and in the control of many homeostatic parameters generate a great deal of interest. The sufficient intake of docosahexaenoic acid that determines not only the normal course of pregnancy and fetal development, but also the optimal development of the child’s higher nervous system is particularly important for the nervous and cardiovascular systems. Clinical trials have demonstrated both the negative outcomes of docosahexaenoic acid deficiency and the positive results of its compensation during pregnancy. This review deals with the current state of this problem and provides today’s international guidelines for the use of docosahexanoic acid in pregnant and breastfeeding women.

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About the authors

I. V Kuznetsova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: ms.smith.ivk@gmail.com
MD, professor, chief scientific officer, Scientific institute of women health

References

  1. Серов В.Н., Сидельникова В.М. Омега-3 полиненасыщенные жирные кислоты в практике врача акушера-гинеколога. Методические рекомендации для врачей акушеров-гинекологов и врачей общей практики. М.; 2008. 24 с. [Serov V.N., Sidelnikova V.M. Omega-3 polyunsaturated fatty acids are widely used in the practice of hynecologist. Method. Recommendation for gynecologists and General practice doctors. M.; 2008. 24 p.]
  2. Koletzko B., Baker S., Cleghorn G., Neto U.F., Gopalan S., Hernell O. et al. Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group. J. Pediatr. Gastroenterol. Nutr. 2005; 41: 584-99.
  3. Koletzko B., Cetin I., Brenna J.; for the Perinatal Lipid Intake Working Group. Dietary fat intakes for pregnant and lactating women. Br. J. Nutr. 2007; 98(5): 873-7. doi: 10.1017/ S0007114507764747.
  4. Lattka E., Illig T., Koletzko B., Heinrich J. Genetic variants of the FADS 1 FADS2 gene cluster as related to essential fatty acid metabolism. Curr. Opin. Lipidol. 2010; 21: 64-9.
  5. Innis S.M. Essential fatty acid transfer and fetal development. Placenta. 2005; 26(Suppl. A): S70-5.
  6. Bazan N.G. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr. Opin. Clin. Nutr. Metab. Care. 2007; 10(2): 136-41
  7. Gonzalez-Periz A., Planaguma A., Gronert K., Miquel R., Lopez-Parra M., Titos E. et al. Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. FASEB J. 2006; 20(14): 2537-9.
  8. Li Q., Ma J., Tan L., Wang C., Li N., Li Y. et al. Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts. Sci. China C Life Sci. 2006; 49(1): 63-72.
  9. Kotani S., Sakaguchi E., Warashina S., Matsukawa N., Ishikura Y., Kiso Y. et al. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci. Res. 2006; 56(2): 159-64.
  10. Lukiw W.J., Bazan N. G. Docosahexaenoic acid and the aging brain. J. Nutr. 2008; 138(12): 2510-4.
  11. Berry C.B., Hayes D., Murphy A., Wiessner M., Rauen T., McBean G.J. Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acid. Brain Res. 2005; 1037(1-2): 123-33.
  12. Levant B., Ozias M.K., Davis P.F., Winter M., Russell K.L., Carlson S.E. et al. Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: interactions with reproductive status in female rats. Psychoneuroendocrinology. 2008; 33(9): 1279-92.
  13. Jiang L.H., Shi Y., Wang L.S., Yang Z.R. The influence of orally administered docosahexaenoic acid on cognitive ability in aged mice. J. Nutr. Biochem. 2009; 20(9): 735-41.
  14. Song C., Manku M.S., Horrobin D.F. Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. J. Nutr. 2008; 138(5): 954-63.
  15. Marza E., Long T., Saiardi A., Sumakovic M., Eimer S., Hall D.H., Lesa G.M. Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling. Mol. Biol. Cell. 2008; 19(3): 833-42.
  16. Xue H., Wan M., Song D., Li Y., Li J. Eicosapentaenoic acid and docosahexaenoic acid modulate mitogen-activated protein kinase activity in endothelium. Vasc. Pharmacol. 2006; 44(6): 434-9.
  17. German O.L., Insua M.F., Gentili C., Rotstein N.P., Politi L.E. Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway. J. Neurochem. 2006; 98(5): 1507-20.
  18. Bazan N.G. The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cell. Mol. Neurobiol. 2006; 26(4-6): 901-13.
  19. Schwellenbach L.J., Olson K.L., McConnell K.J., Stolcpart R.S., Nash J.D., Merenich J.A. The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides. J. Am. Coll. Nutr. 2006; 25(6): 480-5.
  20. Li D., Mann N.J., Sinclair A.J. A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. Lipids. 2006; 41(1): 85-9.
  21. Mebarek S., Ermak N., Benzaria A., Vicca S., Dubois M., Nemoz G. et al. Effects of increasing docosahexaenoic acid intake in human healthy volunteers on lymphocyte activation and monocyte apoptosis. Br. J. Nutr. 2009; 101(6): 851-8.
  22. Li J.J., Huang C.J., Xie D. Anti-obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid. Mol. Nutr. Food Res. 2008; 52(6): 631-45.
  23. Olsen S.F., Osterdal M.L., Salvig J.D., Weber T., Tabor A., Secher N.J. Duration of pregnancy in relation to fish oil supplementation and habitual fish intake: a randomised clinical trial with fish oil. Eur. J. Clin. Nutr. 2007; 61(8): 976-85.
  24. Miyake Y., Sasaki S., Tanaka K., Ohya Y., Miyamoto S., Matsunaga I. et al. Fish and fat intake and prevalence of allergic rhinitis in Japanese females: the Osaka Maternal and Child Health Study. J. Am. Coll. Nutr. 2007; 26(3): 279-87.
  25. Sontrop J., Avison W.R., Evers S.E., Speechley K.N., Campbell M.K. Depressive symptoms during pregnancy in relation to fish consumption and intake of n-3 polyunsaturated fatty acids. Paediatr. Perinat. Epidemiol. 2008; 22(4): 389-99.
  26. Koletzko B., Larque E., Demmelmair H. Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA). J. Perinat. Med. 2007; 35(Suppl. 1): S 5- 11.
  27. Krauss-Etschmann S., Shadid R., Campoy C., Hoster E., Demmelmair H., Jimenez M. et al. Fish oil and folate supplementation of pregnant women and maternal and fetal DHA and EPA plasma levels - a randomized European multicenter trial. Am. J. Clin. Nutr. 2007; 85(5): 1392-400.
  28. Громова О.А., Торшин И.Ю., Егорова Е.Ю. Омега-3 полиненасыщенные жирные кислоты и когнитивное развитие детей. Вопросы современной педиатрии. 2011; 1: 66-72.
  29. Jacobson J.L., Jacobson S.W., Muckle G., Kaplan-Estrin M., Ayotte P., Dewailly E. Beneficial effects of a polyunsaturated fatty acid on infant development: evidence from the inuit of Arctic Quebec. J. Pediatr. 2008; 152(3): 356-64.
  30. Van Eijsden M., Hornstra G., van der Wal M.F., Vrijkotte T.G., Bonsel G.J. Maternal n-3, n-6, and trans fatty acid profile early in pregnancy and term birth weight: a prospective cohort study. Am. J. Clin. Nutr. 2008; 87(4): 887-95.
  31. Muthayya S., Dwarkanath P., Thomas T., Ramprakash S., Mehra R., Mhaskar A. et al. The effect offish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women. Eur. J. Clin. Nutr. 2009; 63(3): 340-6.
  32. Levant B., Radal J.D., Carlson S.E. Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation. Behav. Brain Res. 2004; 152: 49-57.
  33. Hibbeln J.R., Davis J.M., Steer C., Emmett P., Rovers I., Williams C., Golding J. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet. 2007; 369: 578-85.
  34. Yuhas R., Pramuk K., Lien E.L. Human milk fatty acid composition from nine countries varies most in DHA. Lipids. 2006; 41: 851-8.
  35. Horvath A., Koletzko B., Szajewska H. Effect of supplementation of women in high-risk pregnancies with long-chain polyunsaturated fatty acids on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Br. J. Nutr. 2007; 98: 253-9.
  36. Kebanoff M.A., Harper M., Lai Y., Thorp J., Sorokin Y., Varner M.W. et al. Fish consumption, erythrocyte fatty acids, and preterm birth. Obstet. Gynecol. 2011; 117(5): 1071-84.
  37. Rowe D.J., Baker A.C. Perioperative risks and benefits of herbal supplements in aesthetic surgery. Aesthet. Surg. J. 2009; 29(2): 150-7.
  38. Colombo J., Kannass K.N., Shaddy D.J., Kundurthi S., Maikranz J.M., Anderson C.J. et al. Maternal DHA and the development of attention in infancy and toddlerhood. Child Dev. 2004; 75(4): 1254-67.
  39. Jenses C.R., Voigt R.G., Llorente A.M., Peters S.U., Prager T.C., Zou Y.L. et al. Effects of early maternal docosahexaenoic acid intake on neuropsychological status and visual acuity at five years of age of breastfed term infants. J. Pediatr. 2010; 157: 900-5.
  40. Krauss-Etschmann S., Shadid R., Campoy C., Hoster E., Demmelmair H., Jimenez M. et al.; Nutrition and Health Lifestyle (NUHEAL) Study Group. Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial. Am. J. Clin. Nutr. 2007; 85(5): 1392-400.
  41. Jacques C., Levy E., Muckle G., Jacobson S.W., Bastien C., Dewailly E. et al. Long-term effects of prenatal omega-3 fatty acid intake on visual function in school-age children. J. Pediatr. 2011; 158: 83-90.
  42. Koletzko B., Lien E., Agostoni C., Bohles H., Campoy C., Cetin I. et al. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J. Perinat. Med. 2008; 36: 5-14.
  43. Denomme J., Stark K.D., Holub B.J. Directly quantitated dietary (n-3) fatty acid intakes of pregnant Canadian women are lower than current dietary recommendations. J. Nutr. 2005; 135: 206-11.
  44. Interim Summary of Conclusions and Dietary Recommendations on Total Fat& Fatty Acids. From the Joint FAO/WHO Expert Consultation on Fats and Fatty Acids in Human Nutrition. Geneva: WHO; 10-14 November, 2008.

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