FOLIC ACID DOSAGE BEFORE, DURING, AND AFTER PREGNANCY: TO DOT THE I'S AND CROSS THE T'S


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Abstract

Evidence-based studies have repeatedly confirmed the efficiency of using folic acid preparations (in combination with other vitamins in particular) to prevent pregnancy pathologies and fetal malformations. To determine the folic acid dosage that is really effective for the entire population of pregnant women is the most pressing problem of practical obstetrics. This article’s systematized analysis of the results of clinical and epidemiological evidence-based studies has indicated that the folic acid dose that is minimally effective for the prevention of malformations and pregnancy pathologies is 400μg/day. The optimal doses covering the needs of the entire population of pregnant women are 800 μg/day (but not more than 1000 μg/day). The administration of folic acid, beginning during preconception (desirably 2.3 months prior to conception), in combination with other essential micronutrients is more acceptable in terms of the prevention of malformations.

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About the authors

Olga Alekseevna GROMOVA

Russian Satellite Center of Trace Element Institute for UNESCO; Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

Email: unesco/gromova@gmail.com
consultant; MD, professor 153000, Russia, Ivanovo, Sheremetiev pr. 8

Olga Adolfovna LIMANOVA

Russian Satellite Center of Trace Element Institute for UNESCO; Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

Consultant; MD, assistant professor of Pharmacology and Clinical Pharmacology 153000, Russia, Ivanovo, Sheremetievsky Prospect 8

Ivan Yurievich TORSHIN

Russian Satellite Center of Trace Element Institute for UNESCO

Candidate of physico-mathematical sciences, assoc. prof., consultant 109652, Russia, Moscow, Bol. Tichinskyi 26

Nadezhda Vyacheslavovna KERIMKULOVA

Russian Satellite Center of Trace Element Institute for UNESCO; Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

consultant; Ph.D., Assoc., Head. Department of Obstetrics and Gynecology 153000, Russia, Ivanovo, Sheremetievsky Prospect 8

Konstantin Vladimirovich RUDAKOVA

Dorodnitsyn’s Computing Center of RAS

corresponding member, RAS, head of the Department of Intellectual Systems

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