Molecular genetic markers of recurrent candidiasis


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Abstract

Vulvovaginal candidiasis (VVC) is a very widespread disease in women and is common in persons with immunodeficiency. According to different authors, VVC is diagnosed in 30-40% of the women complaining of genital tract discharge. Despite the fact that Candida is a commensal and colonizes the human skin and mucosae, it may result in skin and mucosal injuries and/or generalized infection and, if there are risk factors, the disease may be recurrent. However, recurrent VVC was observed in some cases without apparent risk factors, which may suggest that genetic disorders play a role in an anti- Candida immune response. The polymorphisms in different genes (STAT1, STAT3, CARD9, Dectinl, etc.), which are responsible for chronic/recurrent infection with Candida, were identified. The microorganism’s specific features, such as pathogenicity and virulence factors and antifungal drug resistance, also play an important role in the development of recurrent Candida infection. And only a comprehensive, detailed study of the problem will be able to give an insight into the pathogenesis of the disease and hence to choose an optimal and more sound treatment policy.

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About the authors

Elena A. Mezhevitinova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: e_mezhevitinova@oparina4.ru
MD

Vera N. Prilepskaya

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: v_prilepskaya@oparina4.ru
MD, Professor

Andrew E. Donnikov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: a_donnikov@oparina4.ru
PhD

Shaqeh M. Pogosyan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: shaqpoxos@mail.ru
postgraduate

Patimat R. Abakarova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: p_abakarova@oparina4.ru
PhD

Tatiana V. Brovkina

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: t_brovkina@oparina4.ru
postgraduate

Alla A. Pavlova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: a_pavlova@oparina4.ru
postgraduate

Yulia S. Khlebkova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: y_khlebkova@oparina4.ru
postgraduate

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