EFFICIENCY OF INTRAVAGINAL DEAD SEA PELOID THERAPY FOR FEMALE INFERTILITY


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Abstract

Objective. To comparatively evaluate the efficiency of Dead Sea peloid therapy and medical phonophoresis in combination with ultrasound therapy in infertile women. Subject and methods. The prospective cohort study enrolled 118 early reproductive-aged women with tubal infertility and/or concurrent with chronic endometritis or luteal phase deficiency. Group 1 (a study group) comprised 44 patients who received intravaginal Dead Sea peloid therapy for 10 days. Group 2 (a comparison group) consisted of 47 women who had medical phonophoresis and ultrasound therapy without peloids. Group 3 (a control group) included 27patients who planned to have IVF and refused physiotherapy. To evaluate the efficiency of therapeutic measures, χ 2 and odds ratio (OR) were estimated using 95% confidence interval. Results. Intravaginal Dead Sea peloid therapy reduced the rate of chronic endometritis, restored a menstrual cycle, ovulation, and secretory transformation of the endometrium, normalized progesterone levels, and promoted conception. After peloidotherapy, the conception rate was 38.6% versus 10.6% in the patients who had received phonophoresis and ultrasound (p = 0.0041; OR = 5.3). Intravaginal administration of Dead Sea peloids increased the chance of spontaneous conception by 4.5 times (20.5% versus 2.1%), enhanced the efficiency of IVF by 1.7 times (40% versus 28.6%). Comparison of IVF outcomes in Groups 1 and 3 showed that intravaginal peloidotherapy showed a 3.8-fold increase in conception rates (40% versus 14.8%). Conclusion. Intravaginal Dead Sea peloid administration in early reproductive-aged infertile women contributes to the higher rate of spontaneous conception and substantially improves IVF results.

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About the authors

Tatiana Evgen'evna Belokrinitskaya

Chita State Medical Academy, Ministry of Health of the Russian Federation

Email: tanbell24@mail.ru
M.D., professor, Head of the Department of Obstetrics & Gynecology 672090, Russia, Chita, Gorkiy Str. 39a

Nataly Ivanovna Frolova

Chita State Medical Academy, Ministry of Health of the Russian Federation

Email: taasyaа@mail.ru
Assistant of Professor, Department of Obstetrics & Gynecology 672090, Russia, Chita, Gorkiy Str. 39a

Elena Yur'evna Glotova

Trans-Baikal Territorial Perinatal Center

Email: glotova_elena_66@mail.ru
, manager of polyclinic unit 672000, Russia, Chita, Kokhansky Str. 16

Nadezhda Borisovna Gerasimovich

Trans-Baikal Territorial Perinatal Center

Email: tanbell24@mail.ru
manager of assisted reproductive technology unit 672000, Russia, Chita, Kokhansky Str. 16

Tatyana Veniaminovna Maltseva

"Akademiya Zdorovya" (Health Academy) Medical Center

Email: tmqwerty@rambler.ru
Doctor 672000, Chita, Kokhansky Str. 13

Antonina Nikolaevna Cheuzova

Territorial Medical Rehabilitation Hospital Five

Email: tanbell24@mail.ru
Doctor 672040, Russia, Chita, Gazimurskaya Str. 25

Evgenia Petrovna Belozertseva

Chita State Medical Academy, Ministry of Health of the Russian Federation

Email: belev.chita@mail.ru
Assistant of Professor, Department of Obstetrics & Gynecology 672090, Russia, Chita, Gorkiy Str. 39a

Darya Aleksandrovna Ananyina

Chita State Medical Academy, Ministry of Health of the Russian Federation

Email: tanbell24@mail.ru
resident doctor, Department of Obstetrics & Gynecology 672090, Russia, Chita, Gorkiy Str. 39a

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