Non-instrumental screening for low bone mineral density in women with secondary amenorrhea


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Abstract

The prevalence of low bone mineral density (BMD) in patients with amenorrhea amounts to as much as 52%. Moreover, osteodensitometry is accessible only in large medical centers. Objective. To develop a widely accessible non-instrumental screening methodfor low BMD in women with secondary amenorrhea. Subject and methods. One hundred and nine women (55 patients with premature ovarian failure and 54 with functional hypothalamic amenorrhea) were examined. Basic physical, hormonal, biochemical, and instrumental examinations, including osteodensitometry, were performed. Results. A model was proposed to estimate the probability (P) of low BMD: Р = 1/(1+е -у), where у = 2.67 + 0.22 x DA - 0.29 x BMI + 0.74 x AC (AD is the duration of amenorrhea (years); BMI is the body mass index; AC is the atherogenic coefficient). Conclusion. The proposed formula is a theoretically and clinically grounded screening method for low BMD in patients with secondary amenorrhea, which can identify risk groups to choose the tactics of further examination and combination treatment.

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About the authors

Antonina Alexandrovna Smetnik

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: asmetnik@gmail.com
Junior research worker, Department of gynecological endocrinology

Vera Petrovna Smetnik

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: v_smetnik@oparina4.ru
Ph.D., professor, chief research worker, Department of gynecological endocrinology

Alla Anatolievna Gavisova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: a_gavisova@oparina4.ru
Ph.D., senior research worker, Department of preservation and recovery of reproductive function

Andrey Eugenyevich Donnikov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: a_donnikov@oparina4.ru
Ph.D., senior research worker, Laboratory of molecular-genetic methods

Tatiana Yuryevna Ivanets

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: t_ivanets@oparina4.ru
Ph.D., chief of scientific-diagnostic laboratory

Svetlana Vladimirovna Yureneva

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia

Email: s_yureneva@oparina4.ru
Ph.D., leading research worker, Department of gynecological endocrinology

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