Growth factors as prognostic criteria for conception in IVF cycles


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Abstract

Objective. To establish the optimal time to estimate growth factors during an IVF cycle and to determine their association with conception rate in the cycles. Subject and methods. The present paper gives the results of a comparative analysis of the levels of the examined factors in the cervical mucus (CM) obtained on the day of transvaginal puncture (TVP) of follicles and on that of embryo transfer (ET) into the uterine cavity in 97 infertile women depending on whether pregnancy occurred as a result of IVF. Results. There was a significant increase in the level of granulocyte-macrophage colony-stimulating factor (GM- CSF) and vascular endothelial growth factor (VEGF) (p < 0.01) in the CM obtained on the day of TVP and on that of ET in 50 women with occurred pregnancy versus a group of women (n=47) in whom pregnancy did not. The CM levels of GM-CSF and VEGF on the day of ET were significantly associated (p < 0.05) with conception during IVF cycles and can predict it with a 69% chance. Conclusion. The CM levels of GM- CSF and VEGF on the day of ET are the most informative indicators for assessing endometrial receptivity in the IVF cycle.

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About the authors

Dariko Aleksandrovna Niauri

St. Petersburg State University

Email: office@inform.pu.ru
MD, Professor, Head of the Department of Obstetrics, Gynecology and Reproduction, Medical Faculty

Alexander Mkrtichevich Gzgzyan

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: iagmail@ott.ru
MD, Head of Department of Reproductive Technologies

Igor Yurievich Kogan

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: iagmail@ott.ru
MD, department of Physiology and Pathology of neonatal

Liailia Kharryasovna Dzhemlikhanova

St. Petersburg State University

Email: office@inform.pu.ru
MD, Associate Professor of Obstetrics, Gynecology and Reproduction, Medical Faculty

Inna Otarovna Krikheli

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: iagmail@ott.ru
MD, researcher

Irina Dmitrievna Fedorova

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: iagmail@ott.ru
PhD, Senior Researcher, embryologist of the Department of Reproductive Technologies

Elena Aleksandrovna Lesik

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: lesike@yandex.ru
PhD, Senior Researcher, embryologist

Yulia Najibovna Sharfi

St. Petersburg State University

Email: youlia03@yandex.ru
PhD student of the Department of Obstetrics, Gynecology and Reproduction, Medical Faculty

Evgeniia Mihailovna Shilnikova

St. Petersburg State University

Email: shilnikova-j@mail.ru
PhD student of the Department of genetics, Medical Faculty

Aleksandr Vasil’evich Selyutin

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: a_selutin@yahoo.com
PhD, senior scientist of laboratory of immunology

Sergey Alekseevich Selkov

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: selkovsa@mail.ru
Prof., Sci.D., M.D., Head of laboratory of immunology

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