Growth factors as prognostic criteria for conception in IVF cycles


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Objective. To establish the optimal time to estimate growth factors during an IVF cycle and to determine their association with conception rate in the cycles. Subject and methods. The present paper gives the results of a comparative analysis of the levels of the examined factors in the cervical mucus (CM) obtained on the day of transvaginal puncture (TVP) of follicles and on that of embryo transfer (ET) into the uterine cavity in 97 infertile women depending on whether pregnancy occurred as a result of IVF. Results. There was a significant increase in the level of granulocyte-macrophage colony-stimulating factor (GM- CSF) and vascular endothelial growth factor (VEGF) (p < 0.01) in the CM obtained on the day of TVP and on that of ET in 50 women with occurred pregnancy versus a group of women (n=47) in whom pregnancy did not. The CM levels of GM-CSF and VEGF on the day of ET were significantly associated (p < 0.05) with conception during IVF cycles and can predict it with a 69% chance. Conclusion. The CM levels of GM- CSF and VEGF on the day of ET are the most informative indicators for assessing endometrial receptivity in the IVF cycle.

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作者简介

Dariko Niauri

St. Petersburg State University

Email: office@inform.pu.ru
MD, Professor, Head of the Department of Obstetrics, Gynecology and Reproduction, Medical Faculty

Alexander Gzgzyan

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: iagmail@ott.ru
MD, Head of Department of Reproductive Technologies

Igor Kogan

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: iagmail@ott.ru
MD, department of Physiology and Pathology of neonatal

Liailia Dzhemlikhanova

St. Petersburg State University

Email: office@inform.pu.ru
MD, Associate Professor of Obstetrics, Gynecology and Reproduction, Medical Faculty

Inna Krikheli

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: iagmail@ott.ru
MD, researcher

Irina Fedorova

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: iagmail@ott.ru
PhD, Senior Researcher, embryologist of the Department of Reproductive Technologies

Elena Lesik

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: lesike@yandex.ru
PhD, Senior Researcher, embryologist

Yulia Sharfi

St. Petersburg State University

Email: youlia03@yandex.ru
PhD student of the Department of Obstetrics, Gynecology and Reproduction, Medical Faculty

Evgeniia Shilnikova

St. Petersburg State University

Email: shilnikova-j@mail.ru
PhD student of the Department of genetics, Medical Faculty

Aleksandr Selyutin

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: a_selutin@yahoo.com
PhD, senior scientist of laboratory of immunology

Sergey Selkov

D.O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: selkovsa@mail.ru
Prof., Sci.D., M.D., Head of laboratory of immunology

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