The specific features of MMP1, MMP3, and PAI1 gene polymorphisms in patients with pelvic organ prolapse and stress urinary incontinence


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Abstract

Objective. To assess the relationship between the polymorphism of the MMP1 (rs1799750), MMP3, (rs3025058), and PAI (rs1799768) genes and the risk of pelvic organ prolapse (POP) and stress urinary incontinence (SUI). Subject and methods. Study groups consisted of female patients with Stages 1-4 POP according to the POP-Q scale (n=63) and those with POP and SUI (n=65). Women without POP and complaints of urinary incontinence were included in a control group (n=117). DNA samples were isolatedfrom whole blood. The type of polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism assay. Results. Statistically significant differences were found in the frequency distribution of polymorphisms in MMP1 (rs1799750), MMP3 (rs3025058), and PAI (rs1799768) in the women from the study and control groups. The 1G/1Ggenotype of the MMR-1 gene increases the risk of POP by 2.1 times (OR=2.1; 95% CI, 1.05-4.38), the 5G/5Ggenotype of the MMP3gene enhances the risk of POP by 3.4 times (OR=3.38; 95% CI, 1.64-6.99) and pOp + SUI by 3.3 times (OR=3.29, 95% CI, 1.43-7.57). The PAI 5G/5G genotype increases the risk of POP by 3.2 times (OR=3.16, 95% CI, 1.6-6.2) and POP concurrent with SUI by 5.3 times (OR=5.3, 95% CI, 2.7-10.7). Conclusion. The polymorphism of the MMP1 (rs1799750), MMP3 (rs3025058), and PAI (rs1799768) genes plays a role in the etiology and pathogenesis of POP and CUI.

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About the authors

Elena Ivanovna Rusina

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Email: pismo_rusina@mail.ru
PhD, professor assistant of Operative Gynecology Department

Vitaly Fyodorovich Bezhenar

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Email: bez-vitaly@yandex.ru
MD, professor, Head of Operative Gynecology Department

Tatiyana Eduardovna Ivashchenko

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Email: tivashchenko20ll@mail.ru
MD, Professor of Laboratory of Prenatal Diagnosis of Congenital and Hereditary diseases

Vladimir Stepanovich Pakin

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Email: pakins@list.ru
clinical resident of Laboratory of Prenatal Diagnosis of Congenital and Hereditary diseases

Vladislav Sergeevich Baranov

D.O. Ott Research Institute of Obstetrics and Gynecology, North-Western Branch, Russian Academy of Medical Sciences

Email: baranov@VB2475.spb.edu
MD, professor, Head of Laboratory Prenatal Diagnosis of Congenital and Hereditary diseases

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