The clinical and morphological features of an adhesive process in patients with uterine myoma
- Authors: Kondratovich L.M.1, Kozachenko A.V.1, Kogan E.A.1, Faizullina N.M.1, Adamyan L.V.1
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia
- Issue: No 8 (2014)
- Pages: 71-75
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247267
- ID: 247267
Cite item
Open Access
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Abstract
Objective. To study the clinical and morphological pathogenic features of an evolving adhesive process in patients with uterine myoma after myomectomy. Subject and methods. One hundred and ten patients with uterine myoma were examined. The patients were divided into 2 groups. Group 1 included 34 patients with an adhesive process. Group 2 consisted of 76 patients without this process. Clinical anamnestic, morphological, immunohistochemical examinations and determination of the expression of the markers Ki-67, C-KIT, VEGF, MMP-2, TIMP-2, and collagen types I and III were made. Results. Group 1 showed more myomas with dystrophic changes and growth areas; the commissural fiber displayed the increased expression of the markers of proliferative activity, intercellular interaction, and angiogenesis. The commissural f iber was morphologically characterized by the presence of fatty tissue and cells with the signs of stemness. Conclusion. In women with uterine leiomyoma, peritoneal commissures were clinically and morphologically characterized by the presence of more significant pain syndrome, higher infertility rates, and lower parity. The cells with the signs of stemness, which are located in fatty tissue, are involved in the formation of commissures in women with uterine myoma.
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About the authors
Lyudmila Mikhailovna Kondratovich
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia
Email: klm80sm@mail.ru
aspirant of the Department of operative gynecology
Andrey Vladimirovich Kozachenko
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russiadoctor of medical science, senior researcher in the Department of operative gynecology
Eugenia Altarovna Kogan
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia
Email: e_kogan@oparina4.ru
doctor of medical science, Professor, head of Department
Nufisa Munovarovna Faizullina
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russiasenior researcher in the of Pathanatomical Department
Leila Vladimirovna Adamyan
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia
Email: l_adamyan@oparina4.ru
MD, PhD, Professor, Academician of the Russian Academy of Medical Sciences, Head of the Department of Operative Gynecology
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