The local endometrial expression profile of the growth factor and cytokine genes during the implantation window in chronic endometritis


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Abstract

Objective. To analyze the endometrial expression profile of the growth factor and cytokine genes during the window implantation in chronic endometritis in infertile patients. Subjects and methods. A study group included 39 women with histologically verified chronic endometritis, who planned their treatment using the intro fertilization (IVF) program (Group 1). A comparison group consisted of 39 women with tuboperitoneal infertility without chronic endometritis, who planned their treatment with the intro fertilization (IVF) program (Group 2). The expression of the IGFBP-1, VEGF, IL-15, and IL-18 genes during the implantation window that corresponded to the day of the menstrual cycle of luteinizing hormone + 7 was analyzed. Results. Group 1 patients with chronic endometritis showed 3.4-, 1.5-, 1.5-, and 1.4-fold decreases in the gene expression of IGFBP-1, IL-15, VEGFA, and IL-18 mRNA, respectively. Conclusion. In women with chronic endometritis during the implantation window in the lining of the uterus level of expression of mRNA genes important for successful implantation: IGFBP1, VEGFA, IL15, IL18, is decreased.

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About the authors

V. K Tabolova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tabol93@rambler.ru
graduate student, Department of Fertility Preservation and Restoration

I. E Korneeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: irina.korneeva@inbox.ru
MD, PhD, senior research fellow, Department of Fertility Preservation and Restoration

A. E Donnikov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: donnikov@dna-technology.ru
Ph.D., researcher of the laboratory of molecular genetics methods

O. V Burmenskaya

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bourmenska@mail.ru
Ph.D. researcher of the laboratory of molecular genetics methods

M. A Maslova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mayay20l2@mail.ru
postgraduate student, Department of assisted reproductive technologies

V. Yu Smolnikova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: centr.eko@mail.ru
MD, PhD, senior researcher, Department of assisted reproductive technologies

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