The local endometrial expression profile of the growth factor and cytokine genes during the implantation window in chronic endometritis


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. To analyze the endometrial expression profile of the growth factor and cytokine genes during the window implantation in chronic endometritis in infertile patients. Subjects and methods. A study group included 39 women with histologically verified chronic endometritis, who planned their treatment using the intro fertilization (IVF) program (Group 1). A comparison group consisted of 39 women with tuboperitoneal infertility without chronic endometritis, who planned their treatment with the intro fertilization (IVF) program (Group 2). The expression of the IGFBP-1, VEGF, IL-15, and IL-18 genes during the implantation window that corresponded to the day of the menstrual cycle of luteinizing hormone + 7 was analyzed. Results. Group 1 patients with chronic endometritis showed 3.4-, 1.5-, 1.5-, and 1.4-fold decreases in the gene expression of IGFBP-1, IL-15, VEGFA, and IL-18 mRNA, respectively. Conclusion. In women with chronic endometritis during the implantation window in the lining of the uterus level of expression of mRNA genes important for successful implantation: IGFBP1, VEGFA, IL15, IL18, is decreased.

Толық мәтін

Рұқсат жабық

Авторлар туралы

V. Tabolova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tabol93@rambler.ru
graduate student, Department of Fertility Preservation and Restoration

I. Korneeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: irina.korneeva@inbox.ru
MD, PhD, senior research fellow, Department of Fertility Preservation and Restoration

A. Donnikov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: donnikov@dna-technology.ru
Ph.D., researcher of the laboratory of molecular genetics methods

O. Burmenskaya

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bourmenska@mail.ru
Ph.D. researcher of the laboratory of molecular genetics methods

M. Maslova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mayay20l2@mail.ru
postgraduate student, Department of assisted reproductive technologies

V. Smolnikova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: centr.eko@mail.ru
MD, PhD, senior researcher, Department of assisted reproductive technologies

Әдебиет тізімі

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