Clinical and pathogenetic features of early and late preeclampsia


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Abstract

Objective. To reveal clinical and pathogenetic differences in early and late preeclampsia (PE), by comprehensively examining pregnant women with regard to the morphological and immunohistochemical characteristics of the placental bed. Subjects and methods. The investigation enrolled 150 patients aged 18 to 43 years, who were divided into 3 groups (pregnant women with early and late severe PE and controls). Placental bed tissues were morphologically and immunohistochemically examined. Results. The differences were found in the clinical picture, morphological and immunohistochemical features of the placental bed in early and late PE, which reinforced the heterogeneity of this multisystem disorder and defined various pathogenetic ways and different pregnancy outcomes in early and late PE. Conclusion. The data of this investigation lend support to the need and rationale for dividing PE into early and late forms because of different clinical and pathogenetic mechanisms of development, therefore different pregnancy outcomes for mother and fetus and for searching for the diagnostic markers of the disease and personified therapeutic approaches.

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About the authors

Z. S Khodzhaeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: z_khodzhaeva@oparina4.ru
M.D., Ph.D., Professor, Principal Investigator, Department of Maternal-Fetal Medicine

Yevgeniya Altarovna Kogan

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: koganevg@gmail.com
MD, Prof., I Pathology Department

Natalia Ivanovna Klimenchenko

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_klimenchenko@oparina4.ru
candidate of medical science, head of the 1st obstetric Department of pathology of pregnancy

A. S Akatyeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: Akatyevaas@gmail.com
Postgraduate student

Anastasiya Dmitrievna Safonova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: Adsafonova@mail.ru
postgraduate student

A. M Kholin

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_kholin@oparina4.ru
M.D., Research Associate, Department of Maternal Fetal Medicine

O. V Vavina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_vavina@oparina4.ru
Postgraduate student

Gennady Tikchonovich Sukhikh

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_sukhikh@oparina4.ru
MD, PhD, Professor, Director

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