Clinical and pathogenetic features of early and late preeclampsia


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. To reveal clinical and pathogenetic differences in early and late preeclampsia (PE), by comprehensively examining pregnant women with regard to the morphological and immunohistochemical characteristics of the placental bed. Subjects and methods. The investigation enrolled 150 patients aged 18 to 43 years, who were divided into 3 groups (pregnant women with early and late severe PE and controls). Placental bed tissues were morphologically and immunohistochemically examined. Results. The differences were found in the clinical picture, morphological and immunohistochemical features of the placental bed in early and late PE, which reinforced the heterogeneity of this multisystem disorder and defined various pathogenetic ways and different pregnancy outcomes in early and late PE. Conclusion. The data of this investigation lend support to the need and rationale for dividing PE into early and late forms because of different clinical and pathogenetic mechanisms of development, therefore different pregnancy outcomes for mother and fetus and for searching for the diagnostic markers of the disease and personified therapeutic approaches.

全文:

受限制的访问

作者简介

Z. Khodzhaeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: z_khodzhaeva@oparina4.ru
M.D., Ph.D., Professor, Principal Investigator, Department of Maternal-Fetal Medicine

Yevgeniya Kogan

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: koganevg@gmail.com
MD, Prof., I Pathology Department

Natalia Klimenchenko

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_klimenchenko@oparina4.ru
candidate of medical science, head of the 1st obstetric Department of pathology of pregnancy

A. Akatyeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: Akatyevaas@gmail.com
Postgraduate student

Anastasiya Safonova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: Adsafonova@mail.ru
postgraduate student

A. Kholin

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_kholin@oparina4.ru
M.D., Research Associate, Department of Maternal Fetal Medicine

O. Vavina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_vavina@oparina4.ru
Postgraduate student

Gennady Sukhikh

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_sukhikh@oparina4.ru
MD, PhD, Professor, Director

参考

  1. Ghulmiyyah L., Sibai B. Maternal mortality from preeclampsia/eclampsia. Semin. Perinatol. 2012; 36(1): 56-9.
  2. Lisonkova S., Sabr Y., Mayer C., Young C., Skoll A., Joseph K.S. Maternal morbidity associated with early-onset and late-onset preeclampsia. Obstet. Gynecol. 2014; 124(4): 771-81.
  3. Karahasanovic A., S0rensen S., Nilas L. First trimester pregnancy-associated plasma protein A and human chorionic gonadotropin-beta in early and late pre-eclampsia. Clin. Chem. Lab. Med. 2014; 52(4): 521-5.
  4. Van der Merwe J.L., Hall D.R., Wright C., Schubert P., Grové D. Are early and late preeclampsia distinct subclasses of the disease--what does the placenta reveal? Hypertens. Pregnancy. 2010; 29(4): 457-67.
  5. Воднева Д.Н., Романова В.В., Дубова Е.А., Павлов К.А., Шмаков Р.Г., Щеголев А.И. Клинико-морфологические особенности ранней и поздней преэклампсии. Акушерство и гинекология. 2014; 2: 35-40. [Vodneva D.N., Romanova V.V., Dubova E.A., Pavlov K.A., Shmakov R.G., Shchegolev A.I. The clinical and morphological features of early- and late-onset preeclampsia. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2014; 2: 35-40. (in Russian)]
  6. Ходжаева З.С., Холин А.М., Вихляева Е.М. Ранняя и поздняя преэклампсия: парадигмы патобиологии и клиническая практика. Акушерство и гинекология. 2013; 10: 4-11. [Khodzhaeva Z.S., Kholin A.M., Vikhlyaeva E.M. Early and late preeclampsia: Pathobiology paradigms and clinical practice. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2013; 10: 4-11. (in Russian)]
  7. Ходжаева З.С., Коган Е.А., Сафонова А.Д., Акатьева А.С., Муминова K.T., Файзуллин А.Л. Плацентарное ложе и преэклампсия. Акушерство и гинекология. 2013; 12: 10-5. [Khodzaeva Z.S., Kogan E.A., Safonova A.D., Akatyeva A.S., Muminova K.T., Faizullin A.L. The placental bed and preeclampsia. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2013; 12: 10-5. (in Russian)]
  8. Ходжаева З.С., Акатьева А.С., Холин А.М., Сафонова А.Д., Вавина О.В., Муминова К.Т. Молекулярные детерминанты развития ранней и поздней преэклампсии. Акушерство и гинекология. 2014; 6: 14-9. [Khodzhaeva Z.S., Akatyeva A.S., Kholin A.M., Safonova A.D., Vavina O.V., Muminova K.T. Molecular determinants of the development of early and late preeclampsia. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2014; 6: 14-9. (in Russian)]
  9. Valensise H., Vasapollo B., Gagliardi G., Novelli G.P. Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension. 2008; 52(5): 873-80.
  10. Steegers E.A., von Dadelszen P., Duvekot J.J., Pijnenborg R. Pre-eclampsia. Lancet. 2010; 376(9741): 631-44.
  11. Brosens I., Pijnenborg R., Vercruysse L., Romero R. The “Great Obstetrical Syndromes” are associated with disorders of deep placentation. Am. J. Obstet. Gynecol. 2011; 204(3): 193-201.
  12. Aksornphusitaphong A., Phupong V. Risk factors of early and late onset preeclampsia. J. Obstet. Gynaecol. Res. 2013; 39(3): 627-31.
  13. Robertson W.B., Khong T.Y., Brosens I., De Wolf F., Sheppard B.L., Bonnar J. The placental bed biopsy: review from three European centers. Am. J. Obstet. Gynecol. 1986; 155: 401-12.
  14. Robson S.C., Simpson H., Ball E., Lyall F., Bulmer J.N. Punch biopsy of the human placental bed. Am. J. Obstet. Gynecol. 2002; 187: 1349-55.
  15. Redman C.W.G., Sargent I.L. Immunology of pre-eclampsia. Am. J. Reprod. Immunol. 2010; 63(6): 534-43.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2015
##common.cookie##