Comparative efficiency of additional methods for the diagnosis of premature rupture of the membranes

Objective. To evaluate the efficiency of a test system determining placental α-microglobulin-1 (PAMG-1) in the vaginal discharge as compared to the traditional techniques for the diagnosis of premature rupture of the membranes (PROM). Subjects and methods. One hundred and nine pregnant women with suspected PROM at 28-38 weeks’ gestation were examined. All the women underwent an Amnisure ROM test to determine PAMG-1 in the vaginal discharge and a set of traditional methods used to diagnose PROM (mirror examination, nitrazine pH test, and vaginal bacterioscopy to identify the arborization phenomenon). The final diagnosis was established on the basis of a follow-up of patients during pregnancy and labor. Results. The sensitivity of a rapid test based on the determination of PAMG-1 in the vaginal discharge was 96.5% versus 91.3% in a set of traditional methods (р = 0.1102); the specificity was 98% versus 84.3% (р = 0.0004); the accuracy was 97.2% versus 88.1% (p = 0.0124); the prognostic value of a positive result was 98.2% versus 86.8% (р = 0.0023), and that of a negative result was 96.2% versus 89.6% (р = 0.084), respectively. Conclusion. The f indings have given proof to the efficiency of the Amnisure ROM test versus a set of diagnostic techniques traditionally used in suspected PROM.

premature rupture of the membranes, placental a-microglobulin-1, Amnisure ROM test