CLINICAL AND ANAMNESTIC FEATURES, THE PLACENTA AND PLACENTAL BED IN EARLY AND LATE PREECLAMPSIA


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Abstract

Objective. To reveal clinical and morphological parallels in early and late preeclampsia (PE), by comprehensively examining pregnant women with regard to the morphological and immunohistochemical characteristics of the placenta and placental bed. Subjects and methods. The investigation enrolled 150patients aged 18 to 43 years, who were divided into 3 groups (pregnant women with early and late severe PE and a control group). The tissues of the placental bed and placenta were also morphologically and immunohistochemically examined. Results. The differences were found in the clinical picture, morphological and immunohistochemical features of the placental bed and placenta in early and late PE, which reinforced the heterogeneity of this multisystem disorder and defined various pathogenetic ways of development and different pregnancy outcomes in early and late PE. Conclusion. The data of this investigation lend support to the need and rationale for dividing PE into early and late forms because of different clinical and pathogenetic mechanisms of development, therefore different pregnancy outcomes for mother and fetus and for searching for the diagnostic markers of the disease and personified therapeutic approaches.

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About the authors

Zulfiya S. Khodzhaeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: z_khodzhaeva@oparina4.ru
M.D., Ph.D., Professor, Principal Investigator, Department of Maternal-Fetal Medicine Moscow 117997, Ac. Oparina str. 4, Russia

Roman G. Shmakov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mdshmakov@mail.ru
doctor of medicine, the head of the obstetric physiological department Moscow 117997, Ac. Oparina str. 4, Russia

Yevgeniya A. Kogan

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_koganevg@oparina4.ru
MD. Prof., head of the I Pathology Department Moscow 117997, Ac. Oparina str. 4, Russia

Alexander I. Shchegolev

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: ashegolev@oparina4.ru
doctor of medicine, professor, the head of the pathoanatomical department Moscow 117997, Ac. Oparina str. 4, Russia

Nataliya I. Klimenchenko

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: natalite@list.ru
PhD, head of the 1st obstetric pregnancy pathology department Moscow 117997, Ac. Oparina str. 4, Russia

Albina S. Akatyeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: Akatyevaas@gmail.com
Postgraduate student Moscow 117997, Ac. Oparina str. 4, Russia

Olga V. Vavina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_vavina@oparina4.ru
Postgraduate student, Academician Moscow 117997, Ac. Oparina str. 4, Russia

Daria N. Vodneva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_selivanova@oparina4.ru
postgraduated student of the third year of education Moscow 117997, Ac. Oparina str. 4, Russia

Valeria V. Romanova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: lerfundia@yandex.ru
3rd course postgraduate Moscow 117997, Ac. Oparina str. 4, Russia

Gennady T. Sukhikh

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_sukhikh@oparina4.ru
MD, PhD, Professor, RAS academician, Director Moscow 117997, Ac. Oparina str. 4, Russia

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