Pathogenesis of endometrial polyps in preand postmenopausal patients. Estradiol and progesterone receptor gene expression in their tissues


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Abstract

Objective. To def ine the role of estradiol (nuclear α and β, membrane mER) and progesterone (nuclear α and β, membrane mPR and PGRmCl) receptor gene expression in the occurrence and development of endometrial polyps in pre- and postmenopausal patients to decide which treatment options to be performed. Subjects and methods. A total of 87 patients (29 in premenopause and 58 in postmenopause), including 54 with endometrial fibroglandular polyps (EFGPs) and 21 with endometrial glandular polyps (EGPs), and 12 with endometrial adenomatous polyps (EAPs) were examined. The polyp tissue expression of mER, ER α, ER β, mPR, PGRmC1, PR-А, PR-В was determined by a PCR assay. Results. The patients with EGPs showed the higher polyp tissue expression of ER α, ER β, mPR, and PGRmC1 in premenopause and that of PR-A in postmenopause than did those with EFGPs. The patients with EAPs were found to have signs of dedifferentiation: the lower polyp tissue expression of mER and ER α in premenopause than that in the patients with EFGPs and the higher expression of ER α and ER β in postmenopause than that in the patients with EFGPs. Conclusion. The steroid receptor transcriptome in the tissue of EFGPs, EGPs, and EAPs differs and depends on a woman’s life period. In this connection, we consider it promising to use the data on steroid hormone receptor expression to elaborate individual antirecurrent therapy regimens.

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About the authors

Galina M. Savelyeva

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: gms@cfp.ru
academician RAS, MD, professor, Head of the department of obstetrics and gynecology

Valentina G. Breusenko

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: Breusenkovg@yandex.ru
MD, professor of the department of Obstetrics and Gynecology

Elena N. Kareva

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: elenakareva@mail.ru
MD, Professor of Molecular Pharmacology and Radiobiology

Julia A. Golova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: uasg@mail.ru
MD, Associate Professor of Obstetrics and Gynecology, Faculty of Pediatrics

Dmitry A. Tikhonov

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: tda_0@mail.ru
senior assistant of the Department of Molecular Pharmacology and Radiobiology

Tamara N. Ivanovskaya

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: tn_ivanovskaya@mail.ru
Assistant of the Department of Obstetrics and Gynecology, Faculty of Pediatrics

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