A new procedure for pregravid preparation of the thin endometrium is an alternative to hormonal treatment


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Abstract

Subjects and methods. The investigation included 65 reproductive-aged patients with primary or secondary infertility and the thin endometrium that was untreatable by other therapies and unresponsive to hormonal stimulation conducted in cycles 3-4 months before the investigation. Study group patents (n = 35) underwent endometrial irrigation with the gas mixture (CO 2 and N 2) thrice on days 7, 9, and 11 of the menstrual cycle; control women (n = 30) did not. The gas mixture at 1.3 atmospheres in a volume of 5-6 cm 3 was administered using the transfer embryo catheters attached to a gas cylinder. Ultrasonography was performed on days 7, 9, 11, and 14 days of the menstrual cycle in the study group and on days 7 and 14 in the control group. Results. After administering the gas mixture thrice, there was a significant increase in the endometrial thickness in the study group as compared to the control one (mean endometrial thickness 9.18±1.23 and 5.98±0.66 mm, respectively; p < 0.05). In none case of gas mixture administration, the patients felt unpleasant sensations in the area of small pelvic organs and had adverse reactions. Conclusion. In women with the thin endometrium, the latter’s thickness can be substantially increased by gas mixture irrigation during one menstrual cycle. This procedure may be recommended to prepare the endometrium for further embryo transfers in patients with failed IVF attempts, whose cause was impaired implantation due to the thin endometrium.

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About the authors

Mikhail Grigorevich Shneiderman

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: innamike@lmi.net
MD, PhD, IVF Department

Lev Alekseevich Levkov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: l_levkov@oparina4.ru
MD, PhD

Elena Anatolievna Kalinina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
MD, PhD, Head of IVF Department

Veronika Uruevna Smolnikova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

MD, PhD

Stanislav Vladislavovich Pavlovich

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: stpavlovich@mail.ru
MD, PhD, Secretary

Nona Godovna Mishieva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nondoc555@mail.ru
MD, PhD

Aydar Nazimovich Abubakirov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nondoc555@yahoo.ru
MD, PhD, Head of infertility department

Kamila Ullugbievna Alieva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kaya79@inbox.ru
MD, PhD

Liya Mihailovna Kazaryan

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kazaryanliya@mail.ru
MD, PhD

Artem Anatolievich Aksenenko

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_axenenko@oparina4.ru
MD

Andrei Aleksandrovich Kuzemin

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

MD, PhD

Elena V. Dyuzheva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: dug79@yandex.ru
MD, PhD

N. A Belyaeva

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: dr_belyaeva@mail.ru
MD, PhD

T. H Fatkhudinov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tfat@yandex.ru
MD, PhD

A. V Makarov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: anvitmak@yandex.ru
MD, PhD

A. I Afyan

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_afyan@oparina4
MD, graduate student

I. V Vladimirova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: i_teterina@oparina4.ru
MD, graduate student

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