REGULATORY AND TRANSPORT PROTEINS IN PARTURIENT WOMEN IN THE CARRIAGE OF TORCH INFECTION PATHOGENS OR ANTIBODIES


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Abstract

Objective. To study the levels of α2-macroglobulin (α2MG), lactoferrin (LF), and albumin (ALB) in the serum and amniotic fluid (AF) of the parturient women in the carriage of TORCH infection pathogens or antibodies for the assessment of their role in the development of early neonatal infectious complications. Subjects and methods. The investigators determined the serum concentrations of α 2MG (by quantitative rocket immunoelectrophoresis), LF (by enzyme immunoassay (EIA)), and ALB (by a colorimetric method) and the AF levels of a 2MG, LF (by EIA), and ALB (by a quantitative immunoelectrophoresis) in 40 healthy parturient women at 38-40 weeks’ gestation), in 35 parturient carriers of TORCH infection pathogens or antibodies who had given birth to healthy babies, in parturient carriers of TORCH infection pathogens or antibodies who had given birth to infants with signs of intrauterine infection (IUI), including 18 with Candida albicans, 23 with Staphylococcus aureus, 40 with IgG antibodies to Chlamydia trachomatis, 25 with IgG antibodies to herpes simplex virus, and 32 women with mixed infection. Results. Birth of a full-term baby with signs of the infection is associated with significantly elevated LF levels in the carriage of IgG antibodies to Chlamydia trachomatis, with less elevated LF in the presence of Staphylococcus aureus and in mixed infection; on the contrary, the content of LF was decreased in the carriage of IgG to herpes simplex virus. The IUI infants showed lower serum ALB levels. Higher α 2MG levels were associated with the risk of IUI only in the presence of IgG antibodies to Chlamydia trachomatis in maternal blood. The parturient carriers with IUI had lower LF and higher α 2MG and ALB levels, except the carriers of Staphylococcus aureus as monoinfection. Conclusion. The found changes suggest a covert inflammatory response in parturient women in the carriage of TORCH infection pathogens or antibodies, increased fetoplacental unit permeability, and a decreased antibacterial/ antiviral potential of local protection from pathogenic organisms, which contributes to infection and may be used to predict the course of a neonatal period.

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About the authors

Lyudmila Vladimirovna Renge

Novokuznetsk State Institute for Postgraduate Training of Physicians, Ministry of Health of Russia

Email: perinatal_nk@mail.ru
MD, PhD, Department of Obstetrics and Gynecology Novokuznetsk 654005, Stroiteley str. 5, Russia

Veronica N. Zorina

Novokuznetsk State Institute for Postgraduate Training of Physicians, Ministry of Health of Russia

Email: macroglobulin@yandex.ru
Ph.D., main researcher, laboratory of immunology Novokuznetsk 654005, Stroiteley str. 5, Russia

Lyudmila Grigor'evna Bazhenova

Novokuznetsk State Institute for Postgraduate Training of Physicians, Ministry of Health of Russia

Email: l_bagenova@mail.ru
MD, Professor, Head of the Department of Obstetrics and Gynecology Novokuznetsk 654005, Stroiteley str. 5, Russia

Raisa Mikhaylovna Zorina

Novokuznetsk State Institute for Postgraduate Training of Physicians, Ministry of Health of Russia

Email: macroglobulin@yandex.ru
Ph.D., leading researcher, laboratory of immunology Novokuznetsk 654005, Stroiteley str. 5, Russia

Tamara Semenovna Chirikova

Novokuznetsk State Institute for Postgraduate Training of Physicians, Ministry of Health of Russia

Email: macroglobulin@yandex.ru
junior researcher, laboratory of immunology Novokuznetsk 654005, Stroiteley str. 5, Russia

Nikolay A. Zorin

Novokuznetsk State Institute for Postgraduate Training of Physicians, Ministry of Health of Russia

Email: macroglobulin@yandex.ru
Ph.D., Professor, Head of the laboratory of immunology Novokuznetsk 654005, Stroiteley str. 5, Russia

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