GENE POLYMORPHISM FOR CATECHOLAMINE METABOLIC ENZYMES AND DNA EXCISION REPAIR AS A PREDICTOR OF REPRODUCTIVE LOSSES


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Abstract

Despite the development of modern science and medicine, the problem of miscarriage does not lose its relevance. In parallel with the long studied causes of pregnancy loss, a great deal of recent attention has been paid to its genetic ones. The elaboration of catecholamines, whose physiological concentrations are maintained owing to the generation of the genetically determined enzyme catechol- O-methyltransferase (COMT), is one of the most significant adaptive body systems. The maintenance of the primary structure of DNA, which is required for normal body homeostasis, is accomplished by the coordinated work of a cascade of reactions in the DNA repair system, one of the main components of which is the enzyme 8-oxoguanine DNA glycosylase, which ensures the mechan ism of excision repair. Our investigation included 274 women to examine for the alleles of the COMT gene polymorphism rs4680 and the OGG1 gene polymorphism rs1052133. The findings suggest that the COMT rs5680 A/A and GA genotypes and the OGG1 rs1052133 G/G and C/G genotypes enhance the risk of pregnancy loss in patients with a history of miscarriage.

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About the authors

Oleg Vasilievich Makarov

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: profmakarov@mail.ru
MD, Professor, honored doctor of Russia, head of the Department of obstetrics and gynecology № 1 Moscow 117997, Ostrovityanova str. 1, Russia

Ksenia V. Morozova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: morozovadk@mail.ru
post-graduate student of the Department of obstetrics and gynecology № 1 Moscow 117997, Ostrovityanova str. 1, Russia

Love Efimovna Salnikova

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences

Email: salnikova@vigg.ru
Dr. Biol. Sci., leading researcher, laboratory of ecological genetics Moscow, Gubkina str. 3, Russia

Maryam Borisovna Hadzieva

N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences

graduate student, Junior researcher Moscow, Gubkina str. 3, Russia

Varvara Sergeevna Goncharova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: v_seredenina@mail.ru
post-graduate student of the Department of obstetrics and gynecology № 1 Moscow 117997, Ostrovityanova str. 1, Russia

Nikolai Nikolaevich Lutsenko

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: lnn55@mail.ru
PhD, associate Professor of obstetrics and gynecology № 1 Moscow 117997, Ostrovityanova str. 1, Russia

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