IMPACT OF OBESITY ON TREATMENT OUTCOMES IN AN IN VITRO FERTILIZATION PROGRAM: RETROSPECTIVE STUDY IN 2013


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Abstract

Objective. To study the impact of overweight and obesity on treatment outcomes in an in vitro fertilization (IVF) program. Subjects and methods. A total of 1193 medical records of 18-37-year-old women treated for infertility according to the IVF program at the ART in 2013 were retrospectively analyzed at the V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology (its Director is Academician of the Russian Academy of Sciences G.T. Sukhikh), Ministry of Health of the Russian Federation. The investigation included 432 case histories that met the selection criteria. All the patients were divided into 4 groups: 1) 35 underweight women (body mass index (BMI) < 18.5 kg/m 2); 2) 262 normal weight women (BMI, 18.5-24.99 kg/m 2); 3) 95 overweight patients (BMI 25.0-29.99 kg/m 2); 4) 40 obese patients (BMI > 30.00 kg/m 2). Results. Study groups 1 and 2 were found to have the highest clinical pregnancy rate with reference to embryo transfer. The clinical pregnancy rate in the normal weight women was significantly 1.3 times greater than that in the overweight/obese ones and the rate in the underweight women was 1.7 times greater than that in overweight ones. The reproductive loss rate was highest in Group 1; least in Groups 2 and 3. The miscarriage risk rate was significantly 3.1 times higher in the underweight women than that in the normal weight ones. In the latter, the live birth rate was highest. This indicator was 28.6% in the underweight women and not more than 23% in the overweight and obese ones. Conclusion. A lower IVF treatment efficiency was observed in the overweight and obese women than that in the normal weight one. The former patients should undergo pre-preparation aimed to normalize weights before using ART.

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About the authors

V. K GORSHINOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: chiasma@mail.ru
Post-graduate student, Department of assistive technologies in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

N. V DESYATKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nineks@mail.ru
Post-graduate student, Department of assistive technologies in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

N. A BELYAEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: dr_belyaeva@mail.ru
researcher, Department of assistive technologies in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

V. Yu SMOLNIKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: veronika.smolnikova@mail.ru
MD, Leading researcher, Department of assistive technologies in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

E. A KALININA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
MD, the Head of Department of assistive technologies in infertility treatment Moscow 117997, Ac. Oparina str. 4, Russia

References

  1. Haslam D., Wittert G. Fast facts: obesity. Oxford, UK; 2009.
  2. Prentice A.M. The emerging epidemic of obesity in developing countries. Int. J. Epidemiol. 2006; 35(1): 93-9.
  3. WHO. Media centre fact sheet: obesity and overweight. Available at: http:// www.who.int/mediacentre/factsheets/fs311/en/
  4. Klenov V.E., Jungheim E.S. Obesity and reproductive function: a review of the evidence. Curr. Opin. Obstet. Gynecol. 2014; 26(6): 455-60.
  5. Heslehurst N., Ells L.J., Simpson H., Batterham A., Wilkinson J., Summerbell C.D. Trends in maternal obesity incidence rates, demographic predictors, and health inequalities in 36,821 women over a 15-year period. Br. J. Obstet. Gynaecol. 2007; 114(2): 187-94.
  6. Dokras A., Baredziak L., Blaine J., Syrop C., VanVoorhis B.J., Sparks A. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet. Gynaecol. 2006; 108: 61-9.
  7. Wise L.A., Rothman K.J., Mikkelsen E.M., Sorensen H.T., Riis A., Hatch E.E. An interne t-based prospective study of body size and time-to-pregnancy. Hum. Reprod. 2010; 25: 253-64.
  8. Avc M.E., Sanlikan F., Celik M., Avc A., Kocaer M., Göçmen A. Effects of maternal obesity on antenatal, perinatal, and neonatal outcomes. J. Matern. Fetal Neonatal Med. 2014; 20: 1-13.
  9. Подзолкова Н.М., Агеева М.И., Скворцова М.Ю., Перова Т.В., Никишина И.Д. Течение беременности и перинатальные исходы у женщин с нарушениями жирового обмена. Акушерство и гинекология. 2011; 6: 86-92. [Podzolkova N.M., Ageeva M.I., Skvortsovа M.Yu., Perova T.V., Nikishim I.D. Pregnancy course and perinatal outcomes in women with impaired fat metabolism. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2011; 6: 86-92. (in Russian)]
  10. Zander-Fox D.L., Henshaw R., Hamilton H., Lane M. Does obesity really matter? The impact of BMI on embryo quality and pregnancy outcomes after IVF in women aged №38 years. Aust. N. Z. J. Obstet. Gynaecol. 2012; 52(3): 270-6.
  11. Dokras A., Baredziak L., Blaine J., Syrop C., VanVoorhis B.J., Sparks A. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet. Gynecol. 2006; 108(1): 61-9.
  12. Esinler I., Bozdag G., Yarali H. Impact of isolated obesity on ICSI outcome. Reprod. Biomed. Online. 2008; 17(4): 583-7.
  13. Kilic S., Yilmaz N., Zülfikaroglu E., Sarikaya E., Kose K., Topcu O. et al. Obesity alters retrieved oocyte count and clinical pregnancy rates in high and poor responder women after in vitro fertilization. Arch. Gynecol. Obstet. 2010; 282(1): 89-96.
  14. Rittenberg V., Seshadri S., Sunkara S.K., Sobaleva S., Oteng-Ntim E., Tarek El-Toukhy. Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod. Biomed. Online. 2011; 23(4): 421-39.
  15. Luke B., Brown M.B., Stern J.E., Missmer S.A., Fujimoto V.Y., Leach R. Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates. Hum. Reprod. 2011; 26(1): 245-52.
  16. Depalo R., Garruti G., Totaro I., Panzarino M., Vacca M.P., Giorgino F., Selvaggi L.E. Oocyte morphological abnormalities in overweight women undergoing in vitro fertilization cycles. Gynecol. Endocrinol. 2011; 27(11): 880-4.
  17. Jungheim E.S., Schon S.B., Schulte M.B., DeUgarte D.A., Fowler S.A., Tuuli M.G. IVF outcomes in obese donor oocyte recipients: a systematic review and meta-analysis. Hum. Reprod. 2013; 28(10): 2720-7.
  18. Kumbak B., Oral E., Bukulmez O. Female obesity and assisted reproductive technologies. Semin. Reprod. Med. 2012; 30(6): 507-16.
  19. Singh N., Gupta P., Mittal S., Malhotra N. Correlation of body mass index with outcome of in vitro fertilization in a developing country. Arch. Gynecol. Obstet. 2012; 285(1): 259-63.
  20. Shah D.K., Missmer S.A., Berry K.F., Racowsky C., Ginsburg E.S. Effect of obesity on oocyte and embryo quality in women undergoing in vitro fertilization. Obstet. Gynecol. 2011; 118(1): 63-70.
  21. Legge A., Bouzayen R., Hamilton L., Young D. The impact of maternal body mass index on in vitro fertilization outcomes. J. Obstet. Gynaecol. Can. 2014; 36(7): 613-9.
  22. Čedíková M., Babuška V., Lhotská P., Lošan P., Zech N.H., Králíčková M., Novotný Z. Effect of overweight on the outcome of assisted reproductive technology in infertile women. Ceska Gynekol. 2014; 79(1): 16-21.
  23. Haghighi Z., Rezaei Z., Es-Haghi Ashtiani S. Effects of women’s body mass index on in vitro fertilization success: a retrospective cohort study. Gynecol. Endocrinol. 2012; 28(7): 536-9.
  24. Best practices of ASRM and ESHRE. A joint meeting between the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology. Cortina d’Ampezzo, Italy 1-3 March 2012.
  25. Rittenberg V., Sobaleva S., Ahmad A., Oteng-Ntim E., Bolton V., Khalaf Y. et al. Influence of BMI on risk of miscarriage after single blastocyst transfer. Hum. Reprod. 2011; 26(10): 2642-50.
  26. Machtinger R., Combelles C.M., Missmer S.A., Correia K.F., Fox J.H., Racowsky C. The association between severe obesity and characteristics of failed fertilized oocytes. Hum. Reprod. 2012; 27(11): 3198-207.

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