Specific features of uterine scar formation after cesarean section in undifferentiated connective tissue dysplasia
- Authors: Kan N.E.1, Tyutyunnik V.L.1, Demura T.A.1, Kesova M.I.1
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Issue: No 1 (2015)
- Pages: 93-97
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247416
- ID: 247416
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Abstract
Objective. To study the expression of magnesium channels in the uterine scar after cesarean section in patients with undifferentiated connective tissue dysplasia (USTD). Subjects and methods. A study included 80 patients with uterine scar after cesarean section, who were divided into 2 groups: 1) 40 patients with USTD (a study group) and 2) 40 pregnant women without its signs (a comparison group). Clinical, general laboratory, ultrasound, morphological, and immunohistochemical studies were used. Results. Adequate uterine scars were represented by young connective tissue rich in various f ibroblastic elements located among the plethoric capillaries and small vessels. Inadequate uterine scars were characterized by atrophy and thinning with the formation of a fine fibrous film that covered a uterine wall defect. In the study group, the uterine scars exhibited a lower magnesium channel expression that resulted in increased matrix metalloproteinase (MMP) activity, which, with the reduced activity of tissue inhibitors of metalloproteinases (TIMP), led to enhanced extracellular matrix degradation. Having the normal expression of magnesium channels, the comparison group showed a balanced and unidirectional MMP-9 and TIMP-1 increase that led to more adequate reparations. Conclusion. The lower level of magnesium channels in the smooth muscle cells and fibroblasts is accompanied by the increased activity of MMPs that enhance degradation of collagen fibers, giving rise to connective tissue disorganization and hence an inadequate uterine scar in USTD.
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About the authors
Natalya E. Kan
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: n_kan@oparina4.ru
PhD, MD, the chief physician
Victor L. Tyutyunnik
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: tioutiounnik@mail.ru
PhD, MD, the head of the obstetric observation department
Tatiana A. Demura
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: t_demura@oparina4.ru
PhD, senior researcher of the first pathology department
Marina I. Kesova
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: m_kesova@oparina4.ru
PhD, MD, senior researcher of the obstetric observation department
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