Outcomes of assisted reproductive technology programs in patients with oocyte dysmorphisms
- Authors: Syrkasheva A.G.1, Dolgushina N.V.1, Makarova N.P.1, Agarsheva M.V.2, Kovalskaya E.V.1
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Affiliations:
- Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
- Issue: No 7 (2015)
- Pages: 56-62
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247491
- ID: 247491
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Open Access
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Abstract
Objective. To evaluate the impact of different oocyte dysmorphisms on the outcomes of in vitro fertilization/ intracytoplasmic sperm injection programs. Subjects and methods. A prospective cohort study enrolled 343 patients treated with assisted reproductive technology (ART) programs. According to the presence or absence of oocyte dysmorphisms, the patients were divided into 3 groups: 1) women with cytoplasmic oocyte dysmorphisms; 2) those with extracytoplasmic oocyte dysmorphisms; 3) those with morphologically normal oocytes (a control group). The primary endpoint was an adjusted odds ratio (OR) for the onset of a clinical pregnancy in the examined groups. Results. The rate of ovum fertilization varied greatly among the groups and was minimal in the presence of cytoplasmic dysmorphisms. The greatest number of high-quality embryos was retrieved from the women without oocyte dysmorphisms and the maximum number of Class C embryos that stopped developing was from the patients with cytoplasmic dysmorphisms. The adjusted OR for the onset of a pregnancy among the groups was 1.37 (95% CI: 1.02-1.85) and that in the women with cytoplasmic dysmorphisms as compared to the control group was 3.69 (95% CI: 2.12-6.14). Conclusion. The quality of oocytes plays an important role in fertilization and yield of high-quality of embryos and hence the efficiency of ART programs.
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About the authors
Anastasia Grigorievna Syrkasheva
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: anast.syrkasheva@gmail.com
M.D., Postgraduate of the Department of assistive reproductive technology in the treatment of infertility
Nataliya Vitalievna Dolgushina
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: n_dolgushina@oparina4.ru
M.D., Ph.D., M.P.H., Head of R&D Department
Nataliya Petrovna Makarova
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: np_makarova@oparina4.ru
PhD, Researcher of the Department of assistive reproductive technology in the treatment of infertility
Margarita Valerievna Agarsheva
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Email: agarsheva.m@gmail.com
student
Evgeniya Vladimirovna Kovalskaya
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: e_kovalskaya@oparina4.ru
embryologist of the Department of assistive reproductive technology in the treatment of infertility
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