PATHOGENETIC ASPECTS OF PREECLAMPSIA


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Abstract

Objective. To provide an update on pathogenetic mechanisms for the development of preeclampsia. Material and methods. Literature sources published in the Medline, Pubmed, and other databases were sought. A total of 277 sources on the study of the pathogenesis of preeclampsia at the ultrastructural level were found; 49 of them were included in this review. Results. The preclinical phase of preeclampsia is associated with immunological, molecular, and epigenetic disorders causing structural and functional changes at the cellular and subcellular levels. The study of the problem at the ultrastructural level will be able to diagnose the pathological process at an early stage, to effectively perform prophylaxis, and to reduce maternal and perinatal morbidity rates associated with preeclampsia. Conclusion. The early diagnosis of preeclampsia has not been fully studied. There is a need for further investigation in this area.

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About the authors

Daiana A. Boris

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: dayana_boris@mail.ru
the resident Moscow 117997, Ac. Oparina str. 4, Russia

Natalia E. Kan

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
PhD, MD, the head of the obstetric observation department Moscow 117997, Ac. Oparina str. 4, Russia

Victor L. Tyutyunnik

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
PhD, MD, the head of the obstetric physiological department Moscow 117997, Ac. Oparina str. 4, Russia

Petimat A. Khovkhaeva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: p_hovhaeva@oparina4.ru
the postgraduate student Moscow 117997, Ac. Oparina str. 4, Russia

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