THE SPECIFIC FEATURES OF THE EXPRESSION OF MOLECULAR BIOLOGICAL MARKERS IN GLANDULAR AND FIBROUS ENDOMETRIAL POLYPS IN ELDERLY AND SENILE WOMEN
- Authors: ADAMYAN L.V1, ZAIRATYANTS O.V1, SONOVA M.M1, MELNIKOVA M.S2, BALITSKY E.V2
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Affiliations:
- A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
- Clinical Hospital, Department for Presidential Affairs of the Russian Federation
- Issue: No 11 (2015)
- Pages: 53-57
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247532
- ID: 247532
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Abstract
Objective. To study the expression ofproliferation markers in the cells offibrous and glandular endometrial polyps (FGEP) to specify the pathogenetic aspects of endometrial hyperplastic processes in elderly and senile women. Subjects and methods. Examinations were made in 288elderly and senile women suspected of having endometrial pathology, as evidenced by ultrasound screening, who had undergone hysteroscopy, endometrial biopsy, followed by morphological verification. Immunohistochemical examination was performed in 9 postmenopausal patients with FGEP; a comparison group consisted of 10 reproductive-aged patients. Results. As compared with reproductive-aged women, the menopausal women showed a statistically significantly lower expression of estrogen and progesterone receptors in the nuclei of epithelial and stromal cells of FGEP. The expression of the apoptosis inhibitor Bcl-2 in the epithelial and stromal cells was more marked and that of the apoptosis inductor Bax antigen was, on the contrary, significantly suppressed. The expression of ACP450 was also pronounced manly in the epithelium of the glands. Conclusion. As compared to the reproductive-aged women, the menopausal women had basic molecular biological differences in FGEP, which suggests that the polyps are less related to the effect of estrogens and progesterone and that there is an increased risk for neoplastic transformation.
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About the authors
L. V ADAMYAN
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaAcademician of RAS, MD, Professor, Head of the Department of Reproductive Medicine and Surgery Moscow 127473, Delegatskaya str. 20 bid. 1, Russia
O. V ZAIRATYANTS
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaMD, Professor, Head of the Department of Pathological Anatomy Moscow 127473, Delegatskaya str. 20 bid. 1, Russia
M. M SONOVA
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaMD, associate professor of reproductive medicine and surgery Moscow 127473, Delegatskaya str. 20 bid. 1, Russia
M. S MELNIKOVA
Clinical Hospital, Department for Presidential Affairs of the Russian Federation
Email: mel-ns@yandex.ru
an obstetrician-gynecologist gynecological department Moscow 107150, Losinoostrovskaya str. 45, Russia
E. V BALITSKY
Clinical Hospital, Department for Presidential Affairs of the Russian FederationHead of the Pathology Department Moscow 107150, Losinoostrovskaya str. 45, Russia
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