PAPILLARY TUBAL HYPERPLASIA: CONCURRENCE WITH SEROUS BORDERLINE OVARIAN TUMORS AND MOLECULAR BIOLOGICAL CHARACTERISTICS


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Abstract

Objective. To study changes in the endosalpinx of the fallopian tubes in serous borderline ovarian tumors (SBOT) and high-grade serous ovarian carcinomas (HGSOC) and to determine the molecular biological features of papillary tubal hyperplasia (PTH). Subject and methods. The investigation included the records of 81 patients, 34with SBOT, 33with HGSOC, and 14 with extraovarian pathology. Histological and immunohistochemical (IHC) examinations were performed using the markersp52 and Ki-67. Statistical analysis was carried out applying the Mann-Whitney test. Results. PTH was identified in 73, 21, and 5% of the fallopian tubes in SBOT, HGSOC, and extraovarian pathology, respectively. Serous tubal intraepithelial carcinoma (STIC) was detected only in HGSOC (in 30.2% of the fallopian tubes). In PTH, a weak staining of the nuclei in the fallopian tubal epithelial cells for p53 was seen in 70% at the sites of PTH; Ki-67 expression was low and high in 90 and 10% of the cases, respectively. In all cases of STIC, a high expression of Ki-67 was noted at the sites of high p53 expression. In extraovarian pathology, a weak staining of the nuclei in the fallopian tubal epithelial cells for p53 was observed in 40%; Ki-67% was low in 100%. Conclusion. The development of PTH was shown to be statistically significantly associated with SBOT, IHC examination revealed wild-type p53 accumulation that was typical of PTH, as well as a low proliferative index unlike STC that is characterized by mutantp53 accumulation and high Ki-67 expression. Thus, there may be two different pathways for the pathogenesis of low-grade serous ovarian carcinomas - the development of STIC gives rise to HGSOG; that of PTH leads to SBOT and further low-grade serous ovarian carcinoma.

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About the authors

A. Ѵ ASATUROVA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_asaturova@oparina4.ru
PhD, senior scientific researcher of department l-st anatomic pathology Moscow 117997, Ac. Oparina str. 4, Russia

E. A KOGAN

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kogan@oparina4.ru
professor, Head of the Department of l-st anatomic pathology Moscow 117997, Ac. Oparina str. 4, Russia

L. S EZHOVA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: l_ezhova@oparina4.ru
PhD, senior scientific researcher of department l-st anatomic pathology Moscow 117997, Ac. Oparina str. 4, Russia

N. V ZHARKOV

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_zharkov@oparina4.ru
PhD, scientific researcher of department l-st anatomic pathology Moscow 117997, Ac. Oparina str. 4, Russia

N. M FAIZULLINA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_faizullina@oparina4.ru
PhD, senior scientific researcher of department l-st anatomic pathology Moscow 117997, Ac. Oparina str. 4, Russia

C. N KHABAS

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_khabas@oparina4.ru
Head of the Department of Combined And Complex Treatment Of Gynecological Diseases Moscow 117997, Ac. Oparina str. 4, Russia

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