Bilateral congenital diaphragmatic hernia: Complexities of prenatal prognosis and reproductive counseling of a family


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Abstract

Background. Bilateral congenital diaphragmatic hernia (BCDH) in a neonate and a fetus is a rare congenital malformation with a poor prognosis. Case description. A clinical example has shown that the prenatal diagnosis of BCDH by visual methods is more effective in using not only ultrasonography, but also fetal magnetic resonance imaging. A clinical analysis of the genealogy and phenotypes of all family members is of importance in defining the type of BCDH inheritance and in predicting the future of descendants. Conclusion. Assisted reproductive technologies will be able to reduce the risk for rebirth of an infant with diaphragmatic hernia.

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About the authors

Nadezhda Vasilyevna Zaretskaya

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: znadezda@yandex.ru
candidate of medical science, senior research collaborator, laboratory for reproductive genetics

Artem Alexandrovich Burov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: a_burov@oparina4.ru
anesthesiologist- resuscitator, the department of surgery, resuscitation and intensive therapy of the newborns of the division of neonatology and pediatrics

Ulya Leonidovna Podurovskaya

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: y_podurovskaya@oparina4.ru
PhD, the chief of the department of surgery, resuscitation and intensive therapy of the newborns of the division of neonatology and pediatrics

Sergey Mihaylovich Voevodin

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: s_voevodin@oparina4.ru
MD, professor, head of the visual diagnostics department

Aleksei Nikolayevich Ekimov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: aekimov@gmail.com
Clinical Laboratory Diagnosis Physician, Laboratory of Molecular Genetic Methods

Dmitrii Yurievich Trofimov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: d.trofimov@oparina4.ru
PhD in medical sciences, Head of Laboratory of molecular genetic methods

Vyacheslav Mihaylovich Lyapin

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: v_lyapin@oparina4.ru
doctor-pathologist of 2nd department for pathological anatomy

Alexander Ivanovich Shchegolev

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: ashegolev@oparina4.ru
doctor of medical science, professor, head of 2nd department for pathological anatomy

Irina Mihaylovna Luzhina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: i_lugina@oparina4.ru
doctor-radiologist of the visual diagnostics department

V. N Demidov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: v_demidov@oparina4.ru

Dmitry Nikolayevich Degtyarev

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: d_degtyarev@oparina4.ru
Doctor of Medical Sciences, Professor, Head of department of neonatology and pediatrics

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