Treatment of heartburn in pregnant women


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Heartburn is one of the most common complaints during pregnancy. The paper gives much attention to the choice of a drug from the group of antacids in the context of its fetal safety and effect on the course of pregnancy. It gives the data of Russian and foreign authors supporting the efficacy and safety of gaviscon forte used during pregnancy and the results of a survey of 1082 physicians participating in the management of pregnant women, which have shown that most specialists give preference to antacids, 14.2% of whom do to gaviscon forte.

Full Text

Restricted Access

About the authors

Natalia A. Chukhareva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: 0330348@gmail.com
Junior Researcher of the Therapeutic Department

Elena A. Ushkalova

Peoples’ Friendship University of Russia

Email: eushk@yandex.ru
MD, Professor

Varvara S. Kartseva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kartsevamd@yandex.ru
Junior Researcher of the Therapeutic Department

References

  1. Dowswell T., Neilson J.P. Interventions for heartburn in pregnancy. Cochrane Database Syst. Rev. 2008; (4): CD007065.
  2. Ali R.A., Egan L.J. Gastroesophageal reflux disease in pregnancy. Best Pract. Res. Clin. Gastroenterol. 2007; 21(5): 793-806.
  3. Соколова М.Ю. Экстрагенитальная патология у беременных. Руководство для врачей. М.: МИА; 2011. 336с. [Sokolov M.Yu. Extragenital pathology in pregnant women. Guide for physicians. Moscow: MIA; 2011 336p. (in Russian)]
  4. Rey E., Rodriguez-Artalejo F., Herraiz M.A., Sanchez P., Alvarez-Sanchez A., Escudero M. et al. Gastroesophageal reflux symptoms during and after pregnancy: a longitudinal study. Am. J. Gastroenterol. 2007; 102(11): 2395-400.
  5. Ramu B., Mohan P., Rajasekaran M.S., Jayanthi V. Prevalence and risk factors for gastroesophageal reflux in pregnancy. Indian J. Gastroenterol. 2011; 30(3): 144-7.
  6. Fill Malfertheiner S., Malfertheiner M.V., Monkemuller K., Rohl F.W., Malfertheiner P., Costa S.D. Gastroesophageal reflux disease and management in advanced pregnancy: a prospective survey. Digestion. 2009; 79(2):115-20.
  7. Malfertheiner S.F., Malfertheiner M.V., Kropf S., Costa S.D., Malfertheiner P. A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy. BMC Gastroenterol. 2012; 12: 131.
  8. Gill S.K., Maltepe C., Koren G. The effect of heartburn and acid reflux on the severity of nausea and vomiting of pregnancy. Can. J. Gastroenterol. 2009; 23(4): 270-2.
  9. Gill S.K., Maltepe C., Mastali K., Koren G. The effect of acid-reducing pharmacotherapy on the severity of nausea and vomiting of pregnancy. Obstet. Gynecol. Int. 2009; 2009: 585269.
  10. Richter J.E. Review article: the management of heartburn in pregnancy. Aliment. Pharmacol. Ther. 2005; 22(9): 749-57.
  11. Ивашкин В.Т., Маев И.В., Трухманов А.С., Баранская Е.К., Дронова О.Б., Зайратьянц О.В., Пасечников В.Д., Сайфутдинов Р.Г., Шептулин А.А., Кучерявый Ю.А., Лапина Т.Л., Сторонова О.А., Кайбышева В.О. Гастроэзофагеальная рефлюксная болезнь. Клинические рекомендации. М.; 2014. 23с. [Ivashkin V.T., Maev I.V., Truhmanov A.S., Baranskaya E.K., Dronova O.B., Zairatyants O.V., Pasechnikov V.D., Saifutdinov R.G., Sheptulin A.A., Kucheryavy Yu.A., Lapina T.L., Storonova O.A., Kaybysheva V.O. Gastroesophageal reflux disease. Clinical guidelines. Moscow; 2014. 23p. (in Russian)]
  12. Tytgat G.N., Heading R.C., Muller-Lissner S., Kamm M.A., Scholmerich J., Berstad A. et al. Contemporary understanding and management of reflux and constipation in the general population and pregnancy: a consensus meeting. Aliment. Pharmacol. Ther. 2003; 18(3): 291-301.
  13. Keller J., Frederking D., Layer P. The spectrum and treatment of gastrointestinal disorders during pregnancy. Nat. Clin. Pract. Gastroenterol. Hepatol. 2008; 5(8): 430-43.
  14. Шефер К., Шпильман Х., Феттер К. Лекарственная терапия в период беременности и лактации. М.: Логосфера; 2010. 768с. [Shefer K., Spielman H., Fetter K. Drug therapy during pregnancy and lactation. Moscow: Logosfera; 2010 768p. (in Russian)]
  15. Рубин П., Рэмсэй М., ред. Фармакотерапия при беременности. М.: ГЭОТАР-Медиа; 2010. 296с. [Rubin P., Ramsay M., eds. Pharmacotherapy in pregnancy. Moscow: GEOTAR Media; 2010 296p. (in Russian)]
  16. Picolos M.K., Sims C.R., Mastrobattista J.M., Carroll M.A., Lavis V.R. Milkalkali syndrome in pregnancy. Obstet. Gynecol. 2004; 104(5, Pt2): 1201-4.
  17. Kolnick L., Harris B.D., Choma D.P., Choma N.N. Hypercalcemia in pregnancy: a case of milk-alkali syndrome. J. Gen. Intern. Med. 2011; 26(8): 939-42.
  18. Kleinman G.E., Rodriquez H., Good M.C., Caudle M.R. Hypercalcemic crisis in pregnancy associated with excessive ingestion of calcium carbonate antacid (milk-alkali syndrome): successful treatment with hemodialysis. Obstet. Gynecol. 1991; 78(3, Pt2): 496-99.
  19. Gordon M.V., McMahon L.P., Hamblin P.S. Life-threatening milk-alkali syndrome resulting from antacid ingestion during pregnancy. Med. J. Aust. 2005; 182(7): 350-1.
  20. Ullian M.E., Linas S.L. The milk-alkali syndrome in pregnancy. Case report. Miner. Electrolyte Metab. 1988; 14(4): 208-10.
  21. Bailey C.S., Weiner J.J., Gibby O.M., Penney M.D. Excessive calcium ingestion leading to milk-alkali syndrome. Ann. Clin. Biochem. 2008; 45(5): 527-9.
  22. Robertson W.C. Jr. Calcium carbonate consumption during pregnancy: an unusual cause of neonatal hypocalcemia. J. Child Neurol. 2002; 17(11): 853-5.
  23. Thornton M.D., Chen L., Langhan M.L. Neonatal seizures: soothing a burning topic. Pediatr. Emerg. Care. 2013; 29(10): 1107-10.
  24. Gilbert-Barness E., Barness L.A., Wolff J., Harding C. Aluminum toxicity. Arch. Pediatr. Adolesc. Med. 1998; 152(5): 511-2.
  25. Golding J., Rowland A., Greenwood R., Lunt P. Aluminium sulphate in water in north Cornwall and outcome of pregnancy. Br. Med. J. 1991; 302(6786): 1175-7.
  26. Briggs G., Freeman R., Yaffe S. Drugs in pregnancy and lactation. 9th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2011.
  27. Kane S., Mahadevan U. Рекомендации Института Американской гастроэнтерологической ассоциации по медикаментозному лечению заболеваний желудочно-кишечного тракта у беременных. Клиническая гастроэнтерология и гепатология. Русское издание. 2008; 1: 426-31. [Kane S., Mahadevan U. Recommendations of the Institute of the American Gastroenterological Association medical treatment of diseases of the gastrointestinal tract in pregnant women. Clinical Gastroenterology and Hepatology. Russian edition. 2008; 1: 426-31. (in Russian)]
  28. Mahadevan U. Gastrointestinal medications in pregnancy. Best Pract. Res. Clin. Gastroenterol. 2007; 21(5): 849-77.
  29. Strugala V., Bassin J., Swales V.S., Lindow S.W., Dettmar P.W., Thomas E.C. Assessment of the safety and efficacy of a raft-forming alginate reflux suppressant (Liquid Gaviscon) for the treatment of heartburn during pregnancy. ISRN Obstet. Gynecol. 2012; 2012: 481870.
  30. Онучина Е.В., Горобец Э.А., Рожанский А.А., Цуканов В.В. Симптомы гастроэзофагеальной рефлюксной болезни у беременных. Лечащий врач. 2010; 2: 38-43. Аvailable at: http://www.lvrach. ru/2010/02/12159351/ [Onuchina E.V., Gorobetc E.A., Rozhansky A.A., Tsukanov V.V. The symptoms of gastroesophageal reflux disease in pregnant women. Lechaschiy vrach. 2010; 2: 38-43. Available at: http://www.lvrach. ru/2010/02/12159351/ (in Russian)]
  31. Larson J.D., Patatanian E., Miner P.B. Jr., Rayburn W.F., Robinson M.G. Double-blind, placebo-controlled study of ranitidine for gastroesophageal reflux symptoms during pregnancy. Obstet. Gynecol. 1997; 90(1): 83-7.
  32. Rayburn W., Liles E., Christensen H., Robinson M. Antacids vs. antacids plus non-prescription ranitidine for heartburn during pregnancy. Int. J. Gynaecol. Obstet. 1999; 66(1): 35-7.
  33. Hey V.M., Ostick D.G. Metoclopramide and the gastro-oesophageal sphincter. A study in pregnant women with heartburn. Anaesthesia. 1978; 33(5): 462-5.
  34. Ткачева О.Н., Бевз А., Ушкалова Е., Чухарева Н. Первое Всероссийское фармакоэпидемиологическое исследование «Эпидемиология использования лекарственных средств у беременных»: основные результаты. Акушерство и гинекология. 2011; 4: 112-7. [Tkacheva O.N., Bevz A.Yu., Ushkalova E.A., Chukhareva N.A. The first All-Russian pharmacoepidemiological study «Epidemiology of drug use in pregnant women»: basic results. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2011; 4: 112-7. (in Russian)]
  35. Инструкция по применению лекарственного препарата для медицинского применения Гевискон форте ЛС-002447-291211. In. [Instructions for use of the drug for medical use Gaviscon forte LS-002447-291211. In. (in Russian)]
  36. Strugala V., Dettmar P., Sarratt K., Sykes J., Berry P., Thomas E. A randomized, controlled, crossover trial to investigate times to onset of the perception of soothing and cooling by over-the-counter heartburn treatments. J. Int. Med. Res. 2010; 38(2): 449-57.
  37. Lindow S.W., Regnell P., Sykes J., Little S. An open-label, multicentre study to assess the safety and efficacy of a novel reflux suppressant (Gaviscon Advance) in the treatment of heartburn during pregnancy. Int. J. Clin. Pract. 2003; 57(3): 175-179.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies