NEUROBIOLOGICAL EFFECTS OF PROGESTERONE AND ITS METABOLITES IN OBSTETRIC PRACTICE


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Abstract

Objective. To carry out a systematic analysis of the data available in the current literature on the nonreproductive (neurobiological) effects of progesterone in obstetrics and perinatology and on the prospects of replacement therapy with progesterone in premature neonatal infants with neurologic deficits. Material and methods. The review includes the data of foreign and Russian articles published on this topic in the past 10-15 years and found in the databases Pubmed and Medline. Results. The paper describes the role of the major progesterone neurometabolite allopregnenalone on the development of the fetal central nervous system, myelination and remyelination, and fetal sexual differentiation. It provides evidence that maternal progesterone deficiency may be associated with the development of congenital neurological diseases in newborns. Conclusion. The growing interest in the role of neurosteroids in the production of healthy descendants, as well as experimental and clinical studies in neuroendocrinology open up prospects for translational medicine and for the revision of the traditional views on miscarriage and prevention of preterm birth as a perinatal and obstetric problem.

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About the authors

Zulfiya S. Khodjaeva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: zkhodjaeva@mail.ru
MD, professor, main researcher 117997, Russia, Moscow, Ac. Oparina str. 4

Natalia N. Stenyaeva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nataliasten@mail.ru
MD, PhD, a senior researcher at the Department of Andrology and Urology 117997, Russia, Moscow, Ac. Oparina str. 4

Kirill A. Silaev

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Email: silaevkir@gmail.com
postgraduate student of the Department of Obstetrics and Gynecology, Medical Faculty 127473, Russia, Moscow, Delegatskaya str. 20, bld. 1

Kamilla T. Muminova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kamika91@mail.ru
resident 117997, Russia, Moscow, Ac. Oparina str. 4

Dmitry F. Khritinin

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Corresponding Member of RAS, MD, Professor of Psychiatry and Addiction Medical Faculty Moscow 119991, Trubetskaya str. 8, bld. 2, Russia

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