Genital prolapse: Genetic aspects


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Abstract

Objective. To investigate the impact of the polymorphisms and expression of genes governing the synthesis of components of the connective tissue intercellular matrix and sex hormone receptors on the development of genital prolapse (GP). Material and methods. The data available in the literature on the etiological factors and pathogenetic (including molecular genetic) mechanisms of GP development were analyzed. Results. The paper gives data on the influence of a number of genetic determinants on predisposition to GP. It describes molecular genetic mechanisms in the development of this disease in the presence of single and combined polymorphisms and expression of the genes of connective tissue intercellular matrix components and sex hormone receptors, as well as those regulating the cell cycle and apoptosis. Conclusion. GP is a multietiological disease with an unspecified developmental mechanism. At this moment most found genetic variants are not specific to this disease. In this connection, identification of molecular genetic markers for predisposition to GP in the context of initial manifestations of connective tissue incompetence and pelvic floor laxity weakness and relaxation is of particular relevance in predicting the outcomes of treatment and further progression of GP.

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About the authors

Daria M. Lukyanova

I.M. Sechenov First Moscow State Medical University

Email: dasha-lukyanova9@mail.ru
student of the Centre of Innovative Educational Programs “Future Medicine”

Tatyana Yu. Smolnova

A.I. Evdokimov Moscow State University of Medicine and Dentistry; Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Healthcare of Russia

Email: smoltat@list.ru
MD, PhD, Assistant Professor of the Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Education; Senior Researcher of the Department of Surgical Gynecology

Leyla V. Adamyan

Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Healthcare of Russia; A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of Russia

Email: l_adamyan@oparina4.ru
Academician of the RAS, MD, PhD, Professor, Honored Master of Science of the Russian Federation; Head Specialist in Obstetrics and Gynecology of Ministry of Healthcare of Russia; Deputy Director of Science, Head of the Department of Surgical Gynecology, Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Healthcare of Russia; Head of the Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of Russia.

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