A MODEL FOR PREDICTING THE PROBABILITY OF OBTAINING IMMATURE OOCYTES IN ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS WITH REGARD TO THE GENOTYPE OF PATIENTS


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. To create a multigenic model for predicting the probability of obtaining immature oocytes in assisted reproductive technology programs through preliminary genotyping in patients. Subjects and methods. A total of 160 patients aged 18 to 36 years who were referred for in vitro fertilization (IFV) programs to be treated for infertility were examined during a prospective study. Single nucleotide polymorphisms (SNP) associated with the processes of folliculogenesis and oogenesis were chosen as potential molecular genetic predictors to obtain immature oocytes. Results. A mathematical model that could predict the probability of obtaining immature oocytes in the IVF programs in terms of the patients’ genotype was created. The predictive accuracy for obtaining immature oocytes using the AMHR2 gene polymorphism (-482 A>G), ESR2 G>A [Rsal], LHCGR 935 A>G (Asn312Ser), and LHCGR 872 A>G (Asn291Ser) was 68.6%. The sensitivity was 73.6%; the specificity was 62.5%. Conclusion. Genetic studies make it possible to enhance the accuracy of predicting the outcomes of superovulation induction and to optimize the implementation of IVF programs.

全文:

受限制的访问

作者简介

I. VLADIMIROVA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: inteterina@yandex.ru
scientist of the Department of assistive reproductive technology in the treatment of infertility Moscow 117997, Ac. Oparina str. 4, Russia

E. KALININA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
M.D., Ph D., Head of the Department of assistive reproductive technology in the treatment of infertility Moscow 117997, Ac. Oparina str. 4, Russia

A. DONNIKOV

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
PhD, senior staff scientist of laboratory of molecular genetic methods Moscow 117997, Ac. Oparina str. 4, Russia

参考

  1. Серебренникова К.Г., Кузнецова Е.П., Лапшихин А.А., Иванова ТВ. Современные технологии лечения бесплодия у женщин с оперированными яичниками. Международный журнал экспериментального образования. 2010; 9: 115-7.
  2. Altmae S., Hovatta 0., Stavreus-Evers A., Salumets A. Genetic predictors of controlled ovarian hyperstimulation: where do we stand today? Hum. Reprod. Update. 2011; 17(6): 813-28.
  3. Gearhart J., Coutifaris C. In vitro fertilization, the Nobel Prize, and human embryonic stem cells. Cell Stem Cell. 2011; 8(1): 12-5.
  4. Сухих LT, Сароян T.T., Корнеева И.Е. Иммунные аспекты патофизиологии синдрома гиперстимуляции яичников. Акушерство и гинекология. 2009; 3: 3-6.
  5. O’Brien T.J., Kalmin M.M., Harralson A.F., Clark A.M., GindoffL, Simmens S.J. et al. Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation. Reprod. Biol. Endocrinol. 2013; 11(1): 71.
  6. Alviggi C., Humaidan P, Ezcurra D. Hormonal, functional and genetic biomarkers in controlled ovarian stimulation: tools for matching patients and protocols. Reprod. Biol. Endocrinol. 2012; 10: 9.
  7. Twigt J.M., Hammiche E, Sinclair K.D., Beckers N.G., Visser J.A., Lindemans J. et al. Preconception folic acid use modulates estradiol and follicular responses to ovarian stimulation. J. Clin. Endocrinol. Metab. 2011; 96(2): E322-9.
  8. Калинина E.A., Донников A.E., Владимирова И.В. Молекулярно- генетические предикторы овариального ответа, качества ооцитов и эмбрионов в программах вспомогательных репродуктивных технологий. Акушерство и гинекология. 2015; 3: 21-5.
  9. Desai S.S., Achrekar S.К, Paranjape S.R., Desai S.K., Mangoli V.S., Mahale S.D. Association of allelic combinations of FSHR gene polymorphisms with ovarian response. Reprod. Biomed. Online. 2013; 27(4): 400-6.
  10. Lledo B., Ortiz. J.A., Llacer J., Bernabeu R. Pharmacogenetics of ovarian response. Pharmacogenomics. 2014; 15(6): 885-93.
  11. van Disseldorp J., Franke L., Eijkemans R., Broekmans F, Macklon N., Wijmenga C, Fauser B. Genome-wide analysis shows no genomic predictors of ovarian response to stimulation by exogenous FSH for IVF. Reprod. Biomed. Online. 2011; 22(4): 382-8.
  12. Ferraretti A.P., La Marca A., Fauser B.C., Tarlatzis B., Nargund G., Gianaroli L. ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum. Reprod. 2011; 26(7): 1616-24.
  13. American Society of Reproductive Medicine. Ovarian hyperstimulation syndrome. Fertil. Steril. 2008; 90(5, Suppl.): S188-93.
  14. Delvigne A. Symposium: Update on prediction and management of OHSS. Epidemiology of OHSS. Reprod. Biomed. Online. 2009; 19(1): 8-13.
  15. Баранов В. С. Генетический паспорт-основа индивидуальной и предиктивной медицины. СПб.: H-JI; 2009. 528с. [Baranov V.S. The genetic passport - the basis of individual and predictive medicine. St. Petersburg: H-L; 2009. 528c. (in Russian)]
  16. Boudjenah R., Molina-Gomes D., Torre A., Bergere M., Bailly M., Boitrelle F et al. Genetic polymorphisms influence the ovarian response to rFSH stimulation in patients undergoing in vitro fertilization programs with ICSI. PloS One. 2012;7(6): e38700.
  17. Alvarez C., Garcia-Garrido C., Taronger R., Gonzalez de Merlo G. In vitro maturation, fertilization, embryo development & clinical outcome of human metaphase-I oocytes retrieved from stimulated intracytoplasmic sperm injection cycles. Indian J. Med. Res. 2013; 137(2): 331-8.
  18. Walls M., Junk S., Ryan J.P, Hart R. IVF versus ICSI for the fertilization of in-vitro matured human oocytes. Reprod. Biomed. Online. 2012; 25(6): 603-7.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Bionika Media, 2016