Role of immune mechanisms in the pathogenesis of miscarriage


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Abstract

Objective. To present an update on the immunogenetic mechanisms of miscarriage. Material and methods. Literature was sought in the scientific libraries and Pubmed, Medline, and other databases. 230 sources dealing with the immunological aspects of miscarriage, 36 of which formed the basis for this review, were examined. Results. Recent investigations indicate that there is a close relationship between infection and pregnancy complications, such as miscarriage, placental insufficiency, and preterm delivery. The organism was protected against pathogens with the components of the innate and acquired immunity system. Current cellular and molecular investigations revealed a number of gene polymorphisms in the components of the immune system, which modify an immune response, predisposing to a certain spectrum of infectious agent-related diseases, such as infertility, miscarriage, premature delivery, and placental insufficiency. Conclusion. The investigations conducted in reproductive immunology disclose the molecular genetic mechanisms of miscarriage, which makes it possible to take a new look at the possible causes of miscarriage and to define prospects for prevention and treatment.

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About the authors

Yuliya E. Dobrokhotova

N.I. Pirogov Russian National Research Medical University

Email: pr.dobrohotova@mail.ru
MD, Professor, Head of the Department of Obstetrics and Gynecology

Ludmila V. Gankovskaya

N.I. Pirogov Russian National Research Medical University

Email: lvgan@yandex.ru
MD, Professor, Head of the Department of Immunology

Irina V. Bakhareva

N.I. Pirogov Russian National Research Medical University

Email: iribakhareva@yandex.ru
MD, Professor of the Department of Obstetrics and Gynecology

Oksana A. Svitich

N.I. Pirogov Russian National Research Medical University

Email: svitichoa@yandex.ru
MD, associate Professor of the Department of Immunology

Svetlana V. Malushenko

N.I. Pirogov Russian National Research Medical University

Email: malusvetlana@yandex.ru
postgraduate student of the Department of Obstetrics and Gynecology

Aminat M. Magomedova

N.I. Pirogov Russian National Research Medical University

Email: amidoctor@mail.ru
PhD, assistant Professor of the Department of Obstetrics and Gynecology

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