MENOPAUSAL HORMONE THERAPY: NEW POSSIBILITIES OF REHABILITATION IN ONCOLOGY


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Abstract

Objective. To make a systematic analysis of the data available in the present-day literature on the possibilities of menopausal hormone therapy (MHT) in maintaining the quality of life during menopause, including during premature menopause, and to assess its associated cancer risks. In addition, an attempt was undertaken to answer the question of whether MHT may be used in women at risk for hereditary malignant tumors (in BRCA1 and BRCA2 gene mutation carriers) after prophylactic surgery. Material and methods. The review included the data of the foreign and Russian articles published in the past 10 years, which had been found in Pubmed on this topic. Results. Indications for MHT and its possible regimens in women during menopause, including in those with some cancers, as well as in BRCA1 and BRCA2 gene nutation carriers after prophylactic surgery are described. Conclusion. There is a need for further investigations to elucidate possible cancer risks in the use of MHT, especially in young BRCA1 and ВRCA2 gene nutation carriers. It has been already proven that short-term MHT in these women will aid in alleviating some, but not all postcastration symptoms. The investigations of long-term quality of life and health after removal of the uterine appendages have yet to be completed. It is conceivable that a new era for cancer treatment will come soon.

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About the authors

Yulia G. Payanidi

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Doctor of Medicine, Ph D. in Medical Sciences, Gynecologic Oncology Moscow 115478, Kashirskoe sh. 24, Russia

Kirill I. Zhordania

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Doctor of Medicine, Ph D. in Medical Sciences, Gynecologic Oncology Moscow 115478, Kashirskoe sh. 24, Russia

Vera E. Balan

Moscow Regional Research Institute of Obstetrics and Gynecology, Ministry of Health of the Russian Federation

MD, Professor, Head of the Outpatient Department of Defense 101000, Russia, Moscow, Pokrovka str. 22a

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