PREPARING FOR AN IVF PROTOCOL AFTER SURGERY FOR OVARIAN ENDOMETRIOMAS


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Abstract

Objective. To evaluate the efficiency of preparing for an IVF protocol using dienogest or gonadotropin-releasing hormone (GnRH) agonists in patients after surgery for ovarian endometriomas. Subjects and methods. After surgery for ovarian endometriomas, 144 reproductive-aged patients were divided into 3 groups: 1) 38 patients who had received dienogest in a dose of 2 mg daily 3-6 months before an IVF protocol; 2) 70patients who had taken depot GnRH agonists 3-6 months prior to the protocol; 3) 36patients who had not used hormone therapy before the protocol. Results. The rate of clinical pregnancy in the IVF protocol in the patients after dienogest therapy was 2.5- fold higher (44.7 and 16.7%, respectively; p = 0.01) and that of birth was З-fold higher (36.8% and 11.1%, respectively; p = 0.01) than that in the non-hormone therapy group. The rate of clinical pregnancy and birth in the GnRH agonist group was higher than in the non-treatment group (34.3 and 28.6%, respectively), but without statistical significance. Conclusion. Dienogest 2 mg/day used in patients after surgery for ovarian endometriomas enhances the efficiency of IVF protocols.

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About the authors

I. Yu Kogan

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: ikogan@mail.ru
PhD, MD Saint Petersburg 199034, Mendeleev line, d. 3, Russia

D. A Gerkulov

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

Email: gerkulov@gmail.com
Saint Petersburg 199034, Mendeleev line, d. 3, Russia

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